Potential Events of Drug Interactions among Elderly Hypertensive Patients in Surakarta Hospital

Adhi Wardhana Amrullah, Avianti Eka Dewi Aditya Purwaningsih

2021

Abstract

The use of antihypertensive drugs cannot be separated from the incidence of drug interactions. A study in 2017, showed that of 80 geriatric patients with hypertensive heart disease (HHD), 240 cases of potential drug interactions were found at Moewardi Hospital. This study aims to determine potential incidence of drug interactions in elderly hypertensive patients at Surakarta Hospital. This is an observational study using a cross-sectional method with retrospective data collection of patients in 2018 who were treated at Surakarta Hospital. The inclusion criteria were elderly patients more than 60 years, diagnosed with hypertension with or without comorbidities and receiving antihypertensive and non-antihypertensive drugs. Potential drug interactions were studied theoretically using Medscape.com. The data obtained were analyzed descriptively with cross-tabulation. The results of study were 86 patients who met the inclusion criteria. The theoretical potential for drug interactions was found in 98 cases from 505 cases. Pharmacodynamic drug interactions were most common in the use of bisoprolol with aspirin and furosemide with aspirin in 10 and 8 cases, respectively. The interaction between Valsartan and Atorvastatin as many as 6 cases with the type of pharmacokinetic interaction. It can be concluded that there are more pharmacodynamics than pharmacokinetic drug interactions.

Paper Citation

in Harvard Style

Amrullah A. and Purwaningsih A. (2021). Potential Events of Drug Interactions among Elderly Hypertensive Patients in Surakarta Hospital. In Proceedings of the 3rd International Conference on Social Determinants of Health - Volume 1: ICSDH, ISBN 978-989-758-542-5, pages 294-299. DOI: 10.5220/0010760300003235

in Bibtex Style

@conference{icsdh21,
author={Adhi Wardhana Amrullah and Avianti Eka Dewi Aditya Purwaningsih},
title={Potential Events of Drug Interactions among Elderly Hypertensive Patients in Surakarta Hospital},
booktitle={Proceedings of the 3rd International Conference on Social Determinants of Health - Volume 1: ICSDH,},
year={2021},
pages={294-299},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010760300003235},
isbn={978-989-758-542-5},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 3rd International Conference on Social Determinants of Health - Volume 1: ICSDH,
TI - Potential Events of Drug Interactions among Elderly Hypertensive Patients in Surakarta Hospital
SN - 978-989-758-542-5
AU - Amrullah A.
AU - Purwaningsih A.
PY - 2021
SP - 294
EP - 299
DO - 10.5220/0010760300003235