Analysis on How CRISPR Technology Facilitates Anticancer Therapeutics

Sitian Wang

2021

Abstract

As a novel treatment modality, immunotherapy, based on the principle of boosting the antitumour response, help patients to fight against cancer. Out of many different types of immunotherapies, adoptive T cell therapy, characterized by enhancing immunity and specificity by ex vivo manipulation on patient-derived T cells, has aroused great attention of scholars, who expect to apply it to future cancer treatment. Several CAR-T therapies have been officially approved in clinical use. Nevertheless, post-transfer T cell exhaustion and immunosuppression within the tumour region still constitute the major technical limitations. As an indispensable gene-editing tool with strong capacity in both biomedical research and clinical fields, CRISPR technology has strong potentials in facilitating adoptive T cell therapies to overcome the current barriers through full gene knockout on the engineered T cells. In this paper, the clinical feasibility and future prospect of the combined use of CRISPR-Cas9 and adoptive T cell therapies are analyzed using two latest studies for discussion and comparison. The studies indicate that CRISPR-Cas9 has facilitated to increase T cell persistence and potency in TCR therapy and CAR-T therapy respectively with acceptable safety profile, and it has shed the light for clinical use of CRISPR-Cas9 to increase the therapeutic effectiveness of adoptive T cell therapy. Future investigations are still needed to further assess its clinical safety and to understand the underlying mechanism of how CRISPR-Cas9 helps to extend the survival and increase anti-tumour response of the T cells within the tumour region.

Paper Citation

in Harvard Style

Wang S. (2021). Analysis on How CRISPR Technology Facilitates Anticancer Therapeutics. In Proceedings of the 2nd Conference on Artificial Intelligence and Healthcare - Volume 1: CAIH, ISBN 978-989-758-594-4, pages 128-133. DOI: 10.5220/0011197300003444

in Bibtex Style

@conference{caih21,
author={Sitian Wang},
title={Analysis on How CRISPR Technology Facilitates Anticancer Therapeutics},
booktitle={Proceedings of the 2nd Conference on Artificial Intelligence and Healthcare - Volume 1: CAIH,},
year={2021},
pages={128-133},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0011197300003444},
isbn={978-989-758-594-4},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 2nd Conference on Artificial Intelligence and Healthcare - Volume 1: CAIH,
TI - Analysis on How CRISPR Technology Facilitates Anticancer Therapeutics
SN - 978-989-758-594-4
AU - Wang S.
PY - 2021
SP - 128
EP - 133
DO - 10.5220/0011197300003444