To Explore the Mechanism of Muskone in the Treatment of Breast Cancer based on Network Pharmacology

Haijun Chen, Zhi Wen

2021

Abstract

To investigate the possible mechanism of Muskone in the treatment of Breast cancer through network pharmacology. First, through Pubchem compound structure and Canonical SMILES, then use Swiss Target Prediction and Targetnet database query targets of musk ketone, through Genecards and OMIM database query targets for breast cancer disease, use the Target of muskone and breast cancer disease targets draw the VENN diagram, using the STRING database and Cytosacpe3.7.1 software for network topology parameters selection and muskone core targets for the treatment of breast cancer. Finally, the potential core targets were analyzed through the DAVID platform for GO biological process and enrichment analysis of KEGG signaling pathway. 135 targets of muskone and 1166 targets of breast cancer were obtained. There were 27 intersecting targets between muskone and breast cancer. Cytosacpe3.7.1 software was used to analyze network topology parameters, and 13 core targets of muskone in the treatment of breast cancer were obtained. A total of 78 GO enrichment results were obtained. KEGG enrichment analysis revealed 9 major signaling pathways, including cancer signaling pathway, prolactin signaling pathway, estrogen signaling pathway, etc. Muskone may be used to treat breast cancer through multiple targets and different therapeutic approaches, which provides reference for further study of pharmacodynamic substances and mechanism of action.

Paper Citation

in Harvard Style

Chen H. and Wen Z. (2021). To Explore the Mechanism of Muskone in the Treatment of Breast Cancer based on Network Pharmacology. In Proceedings of the 2nd Conference on Artificial Intelligence and Healthcare - Volume 1: CAIH, ISBN 978-989-758-594-4, pages 249-254. DOI: 10.5220/0011316000003444

in Bibtex Style

@conference{caih21,
author={Haijun Chen and Zhi Wen},
title={To Explore the Mechanism of Muskone in the Treatment of Breast Cancer based on Network Pharmacology},
booktitle={Proceedings of the 2nd Conference on Artificial Intelligence and Healthcare - Volume 1: CAIH,},
year={2021},
pages={249-254},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0011316000003444},
isbn={978-989-758-594-4},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 2nd Conference on Artificial Intelligence and Healthcare - Volume 1: CAIH,
TI - To Explore the Mechanism of Muskone in the Treatment of Breast Cancer based on Network Pharmacology
SN - 978-989-758-594-4
AU - Chen H.
AU - Wen Z.
PY - 2021
SP - 249
EP - 254
DO - 10.5220/0011316000003444