Oral Administration of Bovine Blood Peptide Generated No Adverse Effect on Healthy Rats

Zhenghao Bao, Yuhao Zhang, Ao Wang, He Huang, Yuexin Xu, Hongpeng He, Aqin Wang, Jun Yu

2021

Abstract

IDA (iron deficiency anemia) is a disease with high incidence in many countries. Inorganic iron supplements, typically ferrous sulfate, are widely utilized in the prevention and treatment of IDA. However, the bioavailability of inorganic iron is only 2% to 20%. In addition, the gastrointestinal side effects occur frequently. Heme iron which is isolated from animal blood is a promising choice for IDA patients. Before extensive utilization of heme iron in clinic, safety evaluation is indispensable. In this study, with untreated rats and ferrous sulfate-treated rats as controls, bovine blood peptide which carries heme iron was applied to normal female rats. After 30 days of gavage feeding, no significant difference in body weight and organ coefficient was observed. Serological examination revealed that oral administration of bovine blood peptide did not disrupt iron metabolism nor caused adverse effects on liver and kidney functions. Pathological HE staining of gastrointestinal tract showed that bovine blood peptide induced much less inflammatory irritation than ferrous sulfate. These results suggest that bovine blood peptide is a kind of safe and reliable organic iron supplement for IDA patients.

Paper Citation

in Harvard Style

Bao Z., Zhang Y., Wang A., Huang H., Xu Y., He H., Wang A. and Yu J. (2021). Oral Administration of Bovine Blood Peptide Generated No Adverse Effect on Healthy Rats. In Proceedings of the 2nd Conference on Artificial Intelligence and Healthcare - Volume 1: CAIH, ISBN 978-989-758-594-4, pages 313-317. DOI: 10.5220/0011368100003444

in Bibtex Style

@conference{caih21,
author={Zhenghao Bao and Yuhao Zhang and Ao Wang and He Huang and Yuexin Xu and Hongpeng He and Aqin Wang and Jun Yu},
title={Oral Administration of Bovine Blood Peptide Generated No Adverse Effect on Healthy Rats},
booktitle={Proceedings of the 2nd Conference on Artificial Intelligence and Healthcare - Volume 1: CAIH,},
year={2021},
pages={313-317},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0011368100003444},
isbn={978-989-758-594-4},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 2nd Conference on Artificial Intelligence and Healthcare - Volume 1: CAIH,
TI - Oral Administration of Bovine Blood Peptide Generated No Adverse Effect on Healthy Rats
SN - 978-989-758-594-4
AU - Bao Z.
AU - Zhang Y.
AU - Wang A.
AU - Huang H.
AU - Xu Y.
AU - He H.
AU - Wang A.
AU - Yu J.
PY - 2021
SP - 313
EP - 317
DO - 10.5220/0011368100003444