Prototyping and Early Validation of an Integrated, Electrochemical and Mass Three-sensor Array for Dengue Detection

Ahmad Anwar Zainuddin, Ahmad Anwar Zainuddin, Mohd Afiq Mohd Asri, Cyril Guines, Muhammad Zahid Zabedi, Khin Maung Htay, Abdul Hakim Ab Rahim, Matthieu Chatras, Arnaud Pothier, Anis Nurashikin Nordin

2022

Abstract

This paper presents the current progress towards a lab-on-chip biosensor for early dengue detection, consisting of an integrated sensor with dual-function working electrode that enables in-situ measurements of both electrochemical impedance spectroscopy (EIS) and quartz crystal microbalance (QCM) enclosed in a miniaturized 3D-printed package equipped with electrical contacts and sample fluid delivery to the quartz biosensor array. The sensors consist of an array of three 10 MHz IEQCM biosensors on a single quartz substrate. Early validation is performed for future dengue sensing application. We report the design, optimisation, and fabrication of the sensors, as well as early optimisation and validation of surface bioconjugation of antibodies. This lab-on-chip has the potential to provide accurate dengue detection due to its high sensitivity and dynamic range, as well as providing rapid and early dengue detection in point-of-care settings.

Paper Citation

in Harvard Style

Zainuddin A., Asri M., Guines C., Zabedi M., Htay K., Rahim A., Chatras M., Pothier A. and Nordin A. (2022). Prototyping and Early Validation of an Integrated, Electrochemical and Mass Three-sensor Array for Dengue Detection. In Proceedings of the 15th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2022) - Volume 1: BIODEVICES; ISBN 978-989-758-552-4, SciTePress, pages 204-211. DOI: 10.5220/0010961500003123

in Bibtex Style

@conference{biodevices22,
author={Ahmad Anwar Zainuddin and Mohd Afiq Mohd Asri and Cyril Guines and Muhammad Zahid Zabedi and Khin Maung Htay and Abdul Hakim Ab Rahim and Matthieu Chatras and Arnaud Pothier and Anis Nurashikin Nordin},
title={Prototyping and Early Validation of an Integrated, Electrochemical and Mass Three-sensor Array for Dengue Detection},
booktitle={Proceedings of the 15th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2022) - Volume 1: BIODEVICES},
year={2022},
pages={204-211},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010961500003123},
isbn={978-989-758-552-4},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 15th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2022) - Volume 1: BIODEVICES
TI - Prototyping and Early Validation of an Integrated, Electrochemical and Mass Three-sensor Array for Dengue Detection
SN - 978-989-758-552-4
AU - Zainuddin A.
AU - Asri M.
AU - Guines C.
AU - Zabedi M.
AU - Htay K.
AU - Rahim A.
AU - Chatras M.
AU - Pothier A.
AU - Nordin A.
PY - 2022
SP - 204
EP - 211
DO - 10.5220/0010961500003123
PB - SciTePress