Long Period Grating based Biosensing Technology for the Detection of Vitamin D3

Flavio Esposito, Lucia Sansone, Anubhav Srivastava, Angela Cusano, Stefania Campopiano, Michele Giordano, Agostino Iadiccico

2022

Abstract

The label-free detection of vitamin D by employing fiber optic biosensor is reported in this work. Here, the long period grating (LPG) which is inscribed into a specialty fiber i.e., double cladding fiber (DCF) having W-type refractive index profile, is basically employed as a foundation for biosensing. The wet-chemical etching is performed to the outer cladding of the fiber to induce mode transition phenomenon which resulted in an enhanced sensitivity of -1400 nm/RIU towards surrounding medium along with significant visibility (> 15 dB) of grating’s resonance band. The sensing surface of an LPG device is then coated with a graphene oxide (GO) layer of nanometric thickness providing carboxylic functional groups for grafting of 25-OH-D3 specific antibody for vitamin D3. Finally, the detection of vitamin D3 was tested using concentrations in buffer solutions within the clinical range of 1-100 ng/mL resulting a limit of detection (LOD) lower than 1 ng/mL.

Paper Citation

in Harvard Style

Esposito F., Sansone L., Srivastava A., Cusano A., Campopiano S., Giordano M. and Iadiccico A. (2022). Long Period Grating based Biosensing Technology for the Detection of Vitamin D3 . In Proceedings of the 10th International Conference on Photonics, Optics and Laser Technology - Volume 1: AOMatDev, ISBN 978-989-758-554-8, pages 191-198. DOI: 10.5220/0010973000003121

in Bibtex Style

@conference{aomatdev22,
author={Flavio Esposito and Lucia Sansone and Anubhav Srivastava and Angela Cusano and Stefania Campopiano and Michele Giordano and Agostino Iadiccico},
title={Long Period Grating based Biosensing Technology for the Detection of Vitamin D3 },
booktitle={Proceedings of the 10th International Conference on Photonics, Optics and Laser Technology - Volume 1: AOMatDev,},
year={2022},
pages={191-198},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010973000003121},
isbn={978-989-758-554-8},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 10th International Conference on Photonics, Optics and Laser Technology - Volume 1: AOMatDev,
TI - Long Period Grating based Biosensing Technology for the Detection of Vitamin D3
SN - 978-989-758-554-8
AU - Esposito F.
AU - Sansone L.
AU - Srivastava A.
AU - Cusano A.
AU - Campopiano S.
AU - Giordano M.
AU - Iadiccico A.
PY - 2022
SP - 191
EP - 198
DO - 10.5220/0010973000003121