Protective Effect of Gegen Hawthorn Ginseng Granules on Alcoholic Liver Injury in Mice

Yang Li, Zhenglong Li, Liying Chang, Shujing Zheng, Maoying Yan, Shumin Wang

2022

Abstract

Gegen hawthorn ginseng granules (GHGG) is composed of 6 Chinese medicinal materials including pueraria lobata, hawthorn and ginseng. This study aims to explore the protective effect of GHGG on alcoholic liver injury, and the correlation between oxidative stress, lipid metabolism, inflammation and alcoholic liver disease. The mice were randomly divided into control group and model group, diammonium glycyrrhizinate positive drug group, and GHGG low and high dose groups (GHGG-L and GHGG-H). Oral alcohol was used to establish an acute alcoholic liver injury model. Determination of liver function index ALT and AST levels after administration; Determination of superoxide dismutase (SOD), malondialdehyde (MDA) and reduced glutathione in liver tissue (GSH), TNF-a, IL-1ß, IL-6 and other biochemical indicators; HE staining to analyze the morphological changes of tissue sections. Experimental results show that GHGG can significantly reduce the levels of ALT, AST, and MDA in mice; increase the level of liver tissue The activity of SOD and GSH, and GHGG can significantly inhibit the levels of biochemical indicators such as pro-inflammatory factors TNF-a, IL-1ß, IL-6. The degree of pathological changes in the liver tissue of mice in the GHGG group was significantly reduced. In summary, GHGG can improve ALD by anti-oxidation, inhibiting inflammation, and promoting liver cell regeneration.

Paper Citation

in Harvard Style

Li Y., Li Z., Chang L., Zheng S., Yan M. and Wang S. (2022). Protective Effect of Gegen Hawthorn Ginseng Granules on Alcoholic Liver Injury in Mice. In Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB, ISBN 978-989-758-595-1, pages 146-151. DOI: 10.5220/0011192300003443

in Bibtex Style

@conference{icbeb22,
author={Yang Li and Zhenglong Li and Liying Chang and Shujing Zheng and Maoying Yan and Shumin Wang},
title={Protective Effect of Gegen Hawthorn Ginseng Granules on Alcoholic Liver Injury in Mice},
booktitle={Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,},
year={2022},
pages={146-151},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0011192300003443},
isbn={978-989-758-595-1},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,
TI - Protective Effect of Gegen Hawthorn Ginseng Granules on Alcoholic Liver Injury in Mice
SN - 978-989-758-595-1
AU - Li Y.
AU - Li Z.
AU - Chang L.
AU - Zheng S.
AU - Yan M.
AU - Wang S.
PY - 2022
SP - 146
EP - 151
DO - 10.5220/0011192300003443