Analysis on Intestinal Microbiota in Rheumatoid Arthritis

Ruining Peng

2022

Abstract

Rheumatoid Arthritis (RA) is a prevalent symmetrical facet joint involved systemic autoimmune disease, which is mainly characterized by swelling and deformity of the joints, causing mobility problems and affecting living quality. Factors such as heredity, environment, and microbial infection often lead to the onset of RA, which is also related to immune dysfunctions, but the specific pathogenesis is still unclear. Tens of billions of microbes in the gastrointestinal tract, the biggest immune organ, participate in immunological regulation of the human body, changes in the composition and function of which are closely related to rheumatoid diseases such as RA. Hence, this review focuses on the relationship between intestinal microbes and RA. Based on the analysis and summary of existing materials, it is found that the composition of microbes in the gastrointestinal tract in RA patients is different from that in healthy group. Reductions in Bacteroides and increases in Prevotella are strongly correlated with disease in new-onset untreated rheumatoid arthritis (NORA) subjects. In addition, intestinal microbes and their metabolites affect the production and differentiation of regulatory T cells (Treg cells). Besides, these substances also disrupt the balance between Treg and helper T cells, induce the release of pro-inflammatory factors, interfere with the host immune system, and get involved in the occurrence of autoimmune diseases. The study of the intestinal-articular axis provides a new perspective of RA pathogenesis.

Paper Citation

in Harvard Style

Peng R. (2022). Analysis on Intestinal Microbiota in Rheumatoid Arthritis. In Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB, ISBN 978-989-758-595-1, pages 238-243. DOI: 10.5220/0011197100003443

in Bibtex Style

@conference{icbeb22,
author={Ruining Peng},
title={Analysis on Intestinal Microbiota in Rheumatoid Arthritis},
booktitle={Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,},
year={2022},
pages={238-243},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0011197100003443},
isbn={978-989-758-595-1},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,
TI - Analysis on Intestinal Microbiota in Rheumatoid Arthritis
SN - 978-989-758-595-1
AU - Peng R.
PY - 2022
SP - 238
EP - 243
DO - 10.5220/0011197100003443