Targeting GABA to Cure Anxiety Disorder in Various Methods

Yihui Lu, Jiayi Yuan, Xichen Zhang

2022

Abstract

The number of people suffering from anxiety disorders has risen sharply in recent years. Gamma-aminobutyric acid (GABA) is a neurotransmitter in the central nervous system that inhibits (prevents) nerve activity by restricting nerve transmission. A large number of studies have shown that low GABA levels or GABA system dysfunction can cause anxiety. This article mainly summarizes the treatment and mechanism of anxiety disorders for GABA metabolic uptake, GABAA receptor, and GABAB receptor. The metabolic process of GABA was outlined, by using drugs that increase the expression of GAD, inhibit GABA-T, and block GAT to increased the content of GABA and treat anxiety. The structure of GABAA receptors and how benzodiazepine targets GABAA receptors to treat anxiety disorders were detailed. Finally, anxiety disorders can be treated by GABAB receptor agonist baclofen and positive allosteric modulators (PAMs).

Paper Citation

in Harvard Style

Lu Y., Yuan J. and Zhang X. (2022). Targeting GABA to Cure Anxiety Disorder in Various Methods. In Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB, ISBN 978-989-758-595-1, pages 366-373. DOI: 10.5220/0011208900003443

in Bibtex Style

@conference{icbeb22,
author={Yihui Lu and Jiayi Yuan and Xichen Zhang},
title={Targeting GABA to Cure Anxiety Disorder in Various Methods},
booktitle={Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,},
year={2022},
pages={366-373},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0011208900003443},
isbn={978-989-758-595-1},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,
TI - Targeting GABA to Cure Anxiety Disorder in Various Methods
SN - 978-989-758-595-1
AU - Lu Y.
AU - Yuan J.
AU - Zhang X.
PY - 2022
SP - 366
EP - 373
DO - 10.5220/0011208900003443