Artemisinin Derivatives: Anti-cancer Effects and Mechanisms

Yuwei He, Chang Liu, Linkun Zhang

2022

Abstract

Abstract-Artemisinin derivatives have been studied as anti-malaria drugs in many aspects, while were found anti-cancer affects recently. However, the mechanisms of their anti-cancer effect remain unclear. Research has showed that Artemisinin derivatives may affect the cell cycle of cancer cells through blocking G1 to S phase, and subsequently reduce cell proliferation. Artemisinin derivatives may also cause oncosis and cancer cell apoptosis by promoting Ferroptosis. A new water-soluble derivative, SM1044, was found its anti-cancer ability through inducing apoptosis and blocking cell cycle. Future research is required to better understand the potential mechanisms as well as to expand their clinical applications.

Paper Citation

in Harvard Style

He Y., Liu C. and Zhang L. (2022). Artemisinin Derivatives: Anti-cancer Effects and Mechanisms. In Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB, ISBN 978-989-758-595-1, pages 385-390. DOI: 10.5220/0011211500003443

in Bibtex Style

@conference{icbeb22,
author={Yuwei He and Chang Liu and Linkun Zhang},
title={Artemisinin Derivatives: Anti-cancer Effects and Mechanisms},
booktitle={Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,},
year={2022},
pages={385-390},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0011211500003443},
isbn={978-989-758-595-1},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,
TI - Artemisinin Derivatives: Anti-cancer Effects and Mechanisms
SN - 978-989-758-595-1
AU - He Y.
AU - Liu C.
AU - Zhang L.
PY - 2022
SP - 385
EP - 390
DO - 10.5220/0011211500003443