Research on Active Constituents from Chinese Medicine against Leukemia Targeting ENL based on Molecular Docking

Hao Sun, Jian Tang

2022

Abstract

Leukemia is a class of malignant clonal disease of hematopoietic stem cells. It poses a huge threat to human health. Over the years, progress has been made in using traditional Chinese medicine (TCM) in China to treat and relieve various leukemia symptoms. Erb and he Wan et al noted that ENL protein is a key factor affecting the viability of MLL-r cells in leukemia. Molecular adding or removing molecular group modification on the histone can regulate gene expression A prominent structural feature of the ENL protein is a YEATS domain that identifies a specific acetyl (Ac) on the histone H3. Computer-aided Drug Design (CADD) method has gradually mature and plays an increasingly important role in drug development. Molecular docking is the most widely used and successful method in structure-based drug design. Molecular docking generally refers to the process in which two or more molecules identify each other through geometric and energy matching. Two major topics of molecular docking methods are spatial identification and energy identification between molecules.

Paper Citation

in Harvard Style

Sun H. and Tang J. (2022). Research on Active Constituents from Chinese Medicine against Leukemia Targeting ENL based on Molecular Docking. In Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB, ISBN 978-989-758-595-1, pages 391-396. DOI: 10.5220/0011211800003443

in Bibtex Style

@conference{icbeb22,
author={Hao Sun and Jian Tang},
title={Research on Active Constituents from Chinese Medicine against Leukemia Targeting ENL based on Molecular Docking},
booktitle={Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,},
year={2022},
pages={391-396},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0011211800003443},
isbn={978-989-758-595-1},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,
TI - Research on Active Constituents from Chinese Medicine against Leukemia Targeting ENL based on Molecular Docking
SN - 978-989-758-595-1
AU - Sun H.
AU - Tang J.
PY - 2022
SP - 391
EP - 396
DO - 10.5220/0011211800003443