Targeting Myeloid Cells for Potential Cancer Therapies

Jingwen Pan, Yida Zhang, Wenkai He, Yian Chen

2022

Abstract

Cancer is one of the major health concerns facing the global society. Though significant improvement in cancer therapies have been done, further investigation into alternative treatment approaches are expected to improve clinical outcomes. Myeloid cells are key components that shape the tumor microenvironment. The distribution and recruitment of myeloid cells account for tumor progression and metastasis. Previous studies provided evidence suggesting that the CXCL12/CXCR4 pathway is responsible for recruiting tumor-supportive M2-type macrophages in the oral squamous cell carcinoma (OSCC) model, promoting proliferation and spreading of OSCC cancer cells. CXCL12/CXCR4 pathway also actively affect other types of tumors, like breast cancer. Thus, modifying CXCL12/CXCR4 interaction might be a potential target for cancer treatment. Due to the lack of existing therapies targeting this pathway, we propose a potential treatment targeting the CXCL12/CXCR4 pathway that binds monoclonal antibodies to CXCL12 ligands to eliminate its expression in tumor sites. Positron emission tomography (PET) imaging enables the monitoring and verification of the outcome of this novel design.

Paper Citation

in Harvard Style

Pan J., Zhang Y., He W. and Chen Y. (2022). Targeting Myeloid Cells for Potential Cancer Therapies. In Proceedings of the 1st International Conference on Health Big Data and Intelligent Healthcare - Volume 1: ICHIH, ISBN 978-989-758-596-8, pages 173-180. DOI: 10.5220/0011239000003438

in Bibtex Style

@conference{ichih22,
author={Jingwen Pan and Yida Zhang and Wenkai He and Yian Chen},
title={Targeting Myeloid Cells for Potential Cancer Therapies},
booktitle={Proceedings of the 1st International Conference on Health Big Data and Intelligent Healthcare - Volume 1: ICHIH,},
year={2022},
pages={173-180},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0011239000003438},
isbn={978-989-758-596-8},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st International Conference on Health Big Data and Intelligent Healthcare - Volume 1: ICHIH,
TI - Targeting Myeloid Cells for Potential Cancer Therapies
SN - 978-989-758-596-8
AU - Pan J.
AU - Zhang Y.
AU - He W.
AU - Chen Y.
PY - 2022
SP - 173
EP - 180
DO - 10.5220/0011239000003438