Gingipain Causes Tau Tangle Formation in Alzheimer’s Disease Brains via Regulation of TREM-1

Yiyi Zhu

2022

Abstract

Tau phosphorylation is widely believed as an indicator of Alzheimer’s Disease (AD). Recent evidence suggests that the periodontal pathogen, Porphyromonas gingivalis, is associated with AD development by increasing the level of tau protein in the brain. Gingipain, the major virulence factor of the bacteria, has been described to be involved in the cleavage of the Triggering Receptor Expressed on Myeloid cells 1 (TREM-1). The soluble TREM-1 (sTREM-1) generated was shown to result in the activation of tau phosphorylation. This work aims to uncover the underlying mechanism by which P. gingivalis causes AD by studying the relationship between the level of gingipain, TREM-1 and tau in the brain of mice infected with P. gingivalis. Through this study, a novel mechanism of AD formation may be proposed and can be exploited to generate therapies against the disease.

Paper Citation

in Harvard Style

Zhu Y. (2022). Gingipain Causes Tau Tangle Formation in Alzheimer’s Disease Brains via Regulation of TREM-1. In Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB, ISBN 978-989-758-595-1, pages 626-631. DOI: 10.5220/0011250000003443

in Bibtex Style

@conference{icbeb22,
author={Yiyi Zhu},
title={Gingipain Causes Tau Tangle Formation in Alzheimer’s Disease Brains via Regulation of TREM-1},
booktitle={Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,},
year={2022},
pages={626-631},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0011250000003443},
isbn={978-989-758-595-1},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,
TI - Gingipain Causes Tau Tangle Formation in Alzheimer’s Disease Brains via Regulation of TREM-1
SN - 978-989-758-595-1
AU - Zhu Y.
PY - 2022
SP - 626
EP - 631
DO - 10.5220/0011250000003443