Dissection of the Role of Multidrug Resistance Protein in Cancer

Lihan Xu, Zhouchang Yao, Enqian Zhu

2022

Abstract

Cancer is a major public health problem worldwide, with the mortality estimated to grow for years, especially with the belated access to care due to the pandemic of coronavirus disease 2019. Despite the emergence of various oncology therapies during the past several decades, multi-drug resistance remains an important challenge in cancer healing, especially in chemotherapies. This review includes the classification of chemotherapeutic agents. As over 90% of mortalities in chemotherapies are caused by multi-drug resistance, this study also elaborates the mechanisms of multi-drug resistance, with a deep insight into distinct types of multidrug resistance proteins and the inhibitors related to them. The mechanisms of multidrug resistance proteins are yet to be fully understood, and a few novel inhibitors of multidrug resistance proteins are still under development. Thus, there are challenges for effective chemotherapies overcoming multi-drug resistance. However, a few oncology treatments, such as immunotherapy and targeted drug delivery via DNA nanostructure have weakened the impact of multi-drug resistance. The aim of this review is not only to demonstrate the latest data on the studies of multi-drug resistance but also to offer information to those who are searching for novel oncology therapies with higher cure rates, and plan to contribute to future multidrug resistance studies as well as the emerging discoveries on mechanisms of MRPs.

Paper Citation

in Harvard Style

Xu L., Yao Z. and Zhu E. (2022). Dissection of the Role of Multidrug Resistance Protein in Cancer. In Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB, ISBN 978-989-758-595-1, pages 671-679. DOI: 10.5220/0011254400003443

in Bibtex Style

@conference{icbeb22,
author={Lihan Xu and Zhouchang Yao and Enqian Zhu},
title={Dissection of the Role of Multidrug Resistance Protein in Cancer},
booktitle={Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,},
year={2022},
pages={671-679},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0011254400003443},
isbn={978-989-758-595-1},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,
TI - Dissection of the Role of Multidrug Resistance Protein in Cancer
SN - 978-989-758-595-1
AU - Xu L.
AU - Yao Z.
AU - Zhu E.
PY - 2022
SP - 671
EP - 679
DO - 10.5220/0011254400003443