Combination Therapies of Metastatic Melanoma and Melanoma Brain Metastases

Jiarui Jiang

2022

Abstract

Melanoma is a fatal cancer that develops in melanocytes and has the highest mortality rates in all types of skin cancers. It generally starts as a primary tumor, spreads to adjacent lymph nodes, migrates to distant sites of body through bloodstream, and becomes metastatic in this case. Melanoma brain metastases occur when melanoma cancer cells disperse to the brain. However, compared to the survival rate of melanoma that is localized (stage I, II) or regional (stage III), the survival rate in metastatic melanoma (stage IV) decreases a lot, and it is imperative to find an effective treatment to prolong the survival. As immunotherapy has been developed, one of the methods, checkpoint inhibitors provide higher overall survival and more enduring objective response, which can be both used as monotherapies and combination therapies. In this review, we will focus on the combination of checkpoint inhibitors as an impressive therapy for metastatic melanoma and melanoma brain metastases and summarize its effect on the overall survival and response rate in different clinical trials. The combination of radiotherapy and checkpoint inhibitors for treating melanoma brain metastases is also explored. These combination therapies serve as potent treatments of metastatic melanoma and its brain metastases.

Paper Citation

in Harvard Style

Jiang J. (2022). Combination Therapies of Metastatic Melanoma and Melanoma Brain Metastases. In Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB, ISBN 978-989-758-595-1, pages 686-693. DOI: 10.5220/0011255600003443

in Bibtex Style

@conference{icbeb22,
author={Jiarui Jiang},
title={Combination Therapies of Metastatic Melanoma and Melanoma Brain Metastases},
booktitle={Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,},
year={2022},
pages={686-693},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0011255600003443},
isbn={978-989-758-595-1},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,
TI - Combination Therapies of Metastatic Melanoma and Melanoma Brain Metastases
SN - 978-989-758-595-1
AU - Jiang J.
PY - 2022
SP - 686
EP - 693
DO - 10.5220/0011255600003443