USP22 Promotes Therapeutic Resistance to Prostate Cancer by Deubiquitinating Myc Leading to Increased Myc Regulated Oncogenic Cell Transformation

Ryan Liu

2022

Abstract

USP22 deubiquitinating subunit serving as an oncogenic driver of prostate cancer by regulating cell proliferation and DNA repair. USP22's negative relationship with prostate cancer is well established, but its mechanism of action is not well defined. Here we show that USP22 is progressively overexpressed with prostate cancer progression. USP22 controls androgen receptor signaling and promotes the expression of various genes coregulated by androgen receptor and MYC. This reprogramming also was found to induce transition to therapeutic resistance. Additionally, inhibiting USP22 was found to be beneficial and improved prostate cancer prognosis. Taken together, we demonstrate the promise of USP22 as a therapeutic target for prostate cancer.

Paper Citation

in Harvard Style

Liu R. (2022). USP22 Promotes Therapeutic Resistance to Prostate Cancer by Deubiquitinating Myc Leading to Increased Myc Regulated Oncogenic Cell Transformation. In Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB, ISBN 978-989-758-595-1, pages 702-706. DOI: 10.5220/0011260300003443

in Bibtex Style

@conference{icbeb22,
author={Ryan Liu},
title={USP22 Promotes Therapeutic Resistance to Prostate Cancer by Deubiquitinating Myc Leading to Increased Myc Regulated Oncogenic Cell Transformation},
booktitle={Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,},
year={2022},
pages={702-706},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0011260300003443},
isbn={978-989-758-595-1},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,
TI - USP22 Promotes Therapeutic Resistance to Prostate Cancer by Deubiquitinating Myc Leading to Increased Myc Regulated Oncogenic Cell Transformation
SN - 978-989-758-595-1
AU - Liu R.
PY - 2022
SP - 702
EP - 706
DO - 10.5220/0011260300003443