Epilepsy: GABRB3 Gene and Medical Treatment

Zhichao Dai, Sicheng Pan

2022

Abstract

Epilepsy is one of the most common central nervous system disorders and chronic diseases on the existing human. By writing this essay, we summarize and combine the genetic level with the macroscopic view of the disease. In definition, epilepsy is described as repeating occurrences of sudden excessive or synchronous discharge in the cerebral cortical neuron that leading to various symptoms, depending on the brain region it affects. So, epilepsy is classified into 4 types, focal epilepsy, complex focal seizures, generalized epilepsy, and combined generalized and focal epilepsy. It is worldwide spread, affecting 50 million people, mostly kids, and elders, and the prevalence was slightly higher in males than females. At the genetic and molecular biology level, a strong association of GABRB3(Gamma-aminobutyric acid receptor subunit beta-3) gene and GABAA receptor it encodes for is shown to epilepsy because of the function of the GABAA receptor is inhibiting nerve impulses, mutation of the GABRB3 gene would psychologically lead to anxiety and restlessness, physically disorders like epilepsy. Based on looking and summarizing the macroscopic aspects of the disease, brain activities, and genetic views, we suggest therapies like CRISPR on the GABRB3 gene would likely to provide treatments for epilepsy in the future.

Paper Citation

in Harvard Style

Dai Z. and Pan S. (2022). Epilepsy: GABRB3 Gene and Medical Treatment. In Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB, ISBN 978-989-758-595-1, pages 760-766. DOI: 10.5220/0011294600003443

in Bibtex Style

@conference{icbeb22,
author={Zhichao Dai and Sicheng Pan},
title={Epilepsy: GABRB3 Gene and Medical Treatment},
booktitle={Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,},
year={2022},
pages={760-766},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0011294600003443},
isbn={978-989-758-595-1},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,
TI - Epilepsy: GABRB3 Gene and Medical Treatment
SN - 978-989-758-595-1
AU - Dai Z.
AU - Pan S.
PY - 2022
SP - 760
EP - 766
DO - 10.5220/0011294600003443