The Effect of N-nitrosodimethylamine and Metabolic Activation in the Liver on the Formation of Nasopharyngeal Carcinoma

Waiki Cen

2022

Abstract

Nasopharyngeal carcinoma (NPC) is a common tumor of the head and neck with originates in the nasopharynx cancer, especially in Asia. Moreover, N-nitrosodimethylamine (NDMA) is a highly toxic, carcinogenic nitrosamine, C2H6N2O. It is generally accepted that NDMA is the main cause of NPC. This research aims to investigate the level of NDMA necessary to induce the formation of NPC. To achieve the purpose of this experiment (how much NDMA will cause the formation of NPC) I first injected different amounts of NDMA and pyrazole into the 3 Male Ydd strain mice (inject nothing into the control mice), then carry out a timecourse, lastly use MRI to test the formation of NPC in the Male Ydd strain mice. The result obtained from the experiment is when the level of NDMA is higher than 6.25nmole/200kd of water/mouse and the level of metabolic activation is lowered NPC would be formed (Not found out yet). This study sheds light on the future study about the formation of NPC, also suggests that people should eat less smoked food.

Paper Citation

in Harvard Style

Cen W. (2022). The Effect of N-nitrosodimethylamine and Metabolic Activation in the Liver on the Formation of Nasopharyngeal Carcinoma. In Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB, ISBN 978-989-758-595-1, pages 785-790. DOI: 10.5220/0011295200003443

in Bibtex Style

@conference{icbeb22,
author={Waiki Cen},
title={The Effect of N-nitrosodimethylamine and Metabolic Activation in the Liver on the Formation of Nasopharyngeal Carcinoma},
booktitle={Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,},
year={2022},
pages={785-790},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0011295200003443},
isbn={978-989-758-595-1},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,
TI - The Effect of N-nitrosodimethylamine and Metabolic Activation in the Liver on the Formation of Nasopharyngeal Carcinoma
SN - 978-989-758-595-1
AU - Cen W.
PY - 2022
SP - 785
EP - 790
DO - 10.5220/0011295200003443