Identification of Bakuchiol Targeting Proteins in Human Skin Cells

Yucheng Li

2022

Abstract

Purpose: Bakuchiol is a natural product that is widely used for skin antiaging. Previous studies show that bakuchiol and retinol have similar biological activities despite having no structural resemblance, but the mechanism of action of bakuchiol remains largely unknown. We proposed a regulatory pathway of bakuchiol that is based on the downstream activities of retinol. In this work, we will test a small portion of the proposed pathway—that is, bakuchiol can bind to target proteins different than that of retinol (RARs). Methods: We will design experiments to identify the molecular targets of bakuchiol. We will perform affinity chromatography to isolate bakuchiol targeting proteins, followed by mass spectroscopy to sequence the target proteins. The sequences will be identified using a database. Possible Results: At the end, there are three possible results: (1) Bakuchiol does not bind the target proteins of retinol (RARs) and instead binds other proteins; (2) Bakuchiol only binds RARs. (3) Bakuchiol binds RARs and other proteins. Conclusion: The results of our study will pave the way for understanding the mechanism of action of bakuchiol.

Paper Citation

in Harvard Style

Li Y. (2022). Identification of Bakuchiol Targeting Proteins in Human Skin Cells. In Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB, ISBN 978-989-758-595-1, pages 803-809. DOI: 10.5220/0011296600003443

in Bibtex Style

@conference{icbeb22,
author={Yucheng Li},
title={Identification of Bakuchiol Targeting Proteins in Human Skin Cells},
booktitle={Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,},
year={2022},
pages={803-809},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0011296600003443},
isbn={978-989-758-595-1},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,
TI - Identification of Bakuchiol Targeting Proteins in Human Skin Cells
SN - 978-989-758-595-1
AU - Li Y.
PY - 2022
SP - 803
EP - 809
DO - 10.5220/0011296600003443