Afferent GPi and Efferent from RMTg to VTA of LHb for Reward Omission

Ziqing Zu

2022

Abstract

Reward omission is an essential part in reinforcement learning that has not been fully appreciated, as most of the studies have been focused on the positive reward prediction error (RPE). Therefore, this thesis investigates into the globus pallidus internal segment (GPi), an important afferent of the lateral habenula (LHb), that is responsible for reward omission coding. First, destroying the GPi enables us to find out whether it is the only input for reward omission into the LHb, which is the main area for negative RPE. Then, it will be determined whether Gamma-aminobutyric acid (GABAergic) neurons also involve in the omission signal transmission besides glutamatergic neurons by optogenetically inhibiting GPi glutamatergic neurons. Furthermore, a comparison between the efferent GABAergic neurons of the LHb in the rostromedial tegmental nucleus (RMTg) and the ventral tegmental area (VTA) will be made.

Paper Citation

in Harvard Style

Zu Z. (2022). Afferent GPi and Efferent from RMTg to VTA of LHb for Reward Omission. In Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB, ISBN 978-989-758-595-1, pages 810-816. DOI: 10.5220/0011296800003443

in Bibtex Style

@conference{icbeb22,
author={Ziqing Zu},
title={Afferent GPi and Efferent from RMTg to VTA of LHb for Reward Omission},
booktitle={Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,},
year={2022},
pages={810-816},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0011296800003443},
isbn={978-989-758-595-1},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,
TI - Afferent GPi and Efferent from RMTg to VTA of LHb for Reward Omission
SN - 978-989-758-595-1
AU - Zu Z.
PY - 2022
SP - 810
EP - 816
DO - 10.5220/0011296800003443