Metabolism, Metastasis and Drug Resistance in Cancer

Jiawei Liu

2022

Abstract

Cancer is a heterogeneous disease caused by abnormal cell mutation, which has the characteristics of continuous growth, invasion and metastasis. Despite research advances in cell biology, physiology and pharmacology over the past decades, the mortality of cancer remains a healthcare issue. Current treatments are not very effective in treating advanced tumors. Tumor microenvironment (TME) is a complex environment referring to the surrounding tumor cells, including surrounding blood vessels, immune cells, fibroblasts, bone marrow-derived inflammatory cells, various signal molecules and extracellular matrix (ECM). A large number of studies have proved the key role of tumor microenvironment in the development of cancer. Cancer associated fibroblasts (CAFs) interact with cancer cells to produce growth factors, inflammatory factors and other factors, inhibit the immune system and promote tumor proliferation and invasion. Tumor cells provide good conditions for cancer development by remodeling ECM and glycolysis. This paper has aims and objectives to outline the effects of the interaction between TME and tumor cells on tumor metabolism, metastasis and drug resistance. The molecular mechanism of TME change promoting tumor development is discussed and the current therapeutic strategies for targeting tumor drug resistance are mentioned. Future research with the help of artificial intelligence using large data sets as well as genome sequencing from cancer patients is required to identify novel targets with fewer side effects in different individuals for personalized medicine.

Paper Citation

in Harvard Style

Liu J. (2022). Metabolism, Metastasis and Drug Resistance in Cancer. In Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB, ISBN 978-989-758-595-1, pages 878-882. DOI: 10.5220/0011311900003443

in Bibtex Style

@conference{icbeb22,
author={Jiawei Liu},
title={Metabolism, Metastasis and Drug Resistance in Cancer},
booktitle={Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,},
year={2022},
pages={878-882},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0011311900003443},
isbn={978-989-758-595-1},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,
TI - Metabolism, Metastasis and Drug Resistance in Cancer
SN - 978-989-758-595-1
AU - Liu J.
PY - 2022
SP - 878
EP - 882
DO - 10.5220/0011311900003443