The Application and Prospect of Immune Checkpoints based on PD1 and CTLA4

Ruining Oscar Hang, Jinyu Zhou, Rui Yuan, Huafeng Zheng, Xinyuan Li, Yuze Guo

2022

Abstract

Malignant tumors are currently one of the greatest health challenges the world is facing, ranking first among the various lethal factors that cause death each year. There is a high probability of relapse after treatments once treated with traditional approaches. Immunotherapy typifies a promising treatment method to increase survival rates among patients at advanced stages. So far, however, patients can only receive limited benefits from this novel therapy. In this article, we explore two important immune checkpoints, PD-1 and CTLA-4, and discuss different factors influencing the functions of the immune checkpoint inhibitors. We also review the recent developments in the field from the point of view of combinatory therapies. Research proposals aimed to improve immunotherapies are also included to open new perspectives in enhancing the efficacy and safety of the treatment of malignant tumors.

Paper Citation

in Harvard Style

Oscar Hang R., Zhou J., Yuan R., Zheng H., Li X. and Guo Y. (2022). The Application and Prospect of Immune Checkpoints based on PD1 and CTLA4. In Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB, ISBN 978-989-758-595-1, pages 901-909. DOI: 10.5220/0011312900003443

in Bibtex Style

@conference{icbeb22,
author={Ruining Oscar Hang and Jinyu Zhou and Rui Yuan and Huafeng Zheng and Xinyuan Li and Yuze Guo},
title={The Application and Prospect of Immune Checkpoints based on PD1 and CTLA4},
booktitle={Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,},
year={2022},
pages={901-909},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0011312900003443},
isbn={978-989-758-595-1},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,
TI - The Application and Prospect of Immune Checkpoints based on PD1 and CTLA4
SN - 978-989-758-595-1
AU - Oscar Hang R.
AU - Zhou J.
AU - Yuan R.
AU - Zheng H.
AU - Li X.
AU - Guo Y.
PY - 2022
SP - 901
EP - 909
DO - 10.5220/0011312900003443