The Role of D1 Receptor Medium Spiny Neuron Pathway in Video Gaming Addiction Relapse

Nuo Chen

2022

Abstract

Video game addiction has gained increasing amount of attention as the problem keeps prevailing, especially among adolescents. Inspired by mechanism of cocaine induced substance addiction (D1R-MSN direct pathway) and a potential treatment protocol proposed in previous literature, experiments are done in 40 human subjects to test the mechanism of video game addiction relapse and craving. The results show that low frequency deep brain stimulation of 12 Hz combined with an infusion of drug SCH23390 (D1 receptor antagonist) causes an increase in self-control time, indicating a reversal effect of video game addiction relapse and craving. The same combination of treatment is shown to reduce firing frequency of video game cue induced D1R-MSNs, providing neuroscientific basis for the mechanism of the addiction and the treatment. The combination also proves the role of synaptic change in D1R-MSNs direct pathway in the cause of video game addiction relapse and craving. The mGluR1 dependent long-term depression (LTD) reducing total glutamate release and surface expression of AMPA receptors might be the mechanism behind the treatment.

Paper Citation

in Harvard Style

Chen N. (2022). The Role of D1 Receptor Medium Spiny Neuron Pathway in Video Gaming Addiction Relapse. In Proceedings of the 1st International Conference on Health Big Data and Intelligent Healthcare - Volume 1: ICHIH, ISBN 978-989-758-596-8, pages 465-470. DOI: 10.5220/0011372200003438

in Bibtex Style

@conference{ichih22,
author={Nuo Chen},
title={The Role of D1 Receptor Medium Spiny Neuron Pathway in Video Gaming Addiction Relapse},
booktitle={Proceedings of the 1st International Conference on Health Big Data and Intelligent Healthcare - Volume 1: ICHIH,},
year={2022},
pages={465-470},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0011372200003438},
isbn={978-989-758-596-8},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st International Conference on Health Big Data and Intelligent Healthcare - Volume 1: ICHIH,
TI - The Role of D1 Receptor Medium Spiny Neuron Pathway in Video Gaming Addiction Relapse
SN - 978-989-758-596-8
AU - Chen N.
PY - 2022
SP - 465
EP - 470
DO - 10.5220/0011372200003438