Influence of Epigenetic Differences on the Etiology of Bipolar Disorder and Schizophrenia

Zhiyu Yan

2022

Abstract

Schizophrenia and bipolar disorder are two mental disorders that have attracted worldwide attention. However, The role of DNA methylation in epigenetics in schizophrenia and bipolar disorder is unclear. This paper investigates the role of epigenetics in the pathogenesis of schizophrenia and bipolar disorder. Genome-wide analyses of monozygotic twins have identified specific genetic loci at which DNA methylation may be responsible for schizophrenia and bipolar disorder. Certain conclusions were made by genome-wide DNA methylation analysis of DNA samples from identical twins with inconsistent major psychiatric disorders. In twins with schizophrenia, the largest differential methylation region associated with mental illness was significant hypomethylation of the ST6GALNAC1 promoter, which overlaps with previously reported rare schizophrenia genomes. The average difference in DNA methylation at this locus is 6%, but there is considerable variation between families, with some twins even showing a 20% difference in methylation. These results suggest that DNA methylation differences play a role in phenotypic differences in identical twins and may influence the etiology of schizophrenia and bipolar disorder to some extent.

Paper Citation

in Harvard Style

Yan Z. (2022). Influence of Epigenetic Differences on the Etiology of Bipolar Disorder and Schizophrenia. In Proceedings of the 1st International Conference on Health Big Data and Intelligent Healthcare - Volume 1: ICHIH, ISBN 978-989-758-596-8, pages 471-477. DOI: 10.5220/0011372300003438

in Bibtex Style

@conference{ichih22,
author={Zhiyu Yan},
title={Influence of Epigenetic Differences on the Etiology of Bipolar Disorder and Schizophrenia},
booktitle={Proceedings of the 1st International Conference on Health Big Data and Intelligent Healthcare - Volume 1: ICHIH,},
year={2022},
pages={471-477},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0011372300003438},
isbn={978-989-758-596-8},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st International Conference on Health Big Data and Intelligent Healthcare - Volume 1: ICHIH,
TI - Influence of Epigenetic Differences on the Etiology of Bipolar Disorder and Schizophrenia
SN - 978-989-758-596-8
AU - Yan Z.
PY - 2022
SP - 471
EP - 477
DO - 10.5220/0011372300003438