Preventive Effect of Lactobacillus Plantarum Isolated from Altay Traditional Fermented Yogurt on DSS-induced Colitis in Mice

Xin Zhou

2022

Abstract

In this study, Preventive effect of Lactobacillus plantarum isolated from Altay traditional fermented yogurt on DSS-induced colitis in mice has been measured. The BALB/c mice were randomly divided into five groups: NC group (normal controls), DSS group (14-day orally administration of saline + 7-day 4% DSS exposure from day 8), low-dose LP-A group (LP-A-L, 1×108 CFU/kg, 7-day orally administration of LP-AL + 7-day 4% DSS exposure from day 8), high-dose LP-A group (LP-A-H, 1×109 CFU/kg, 7-day orally administration of LP-A-H + 7-day 4% DSS exposure from day 8), positive control group (sulfasalazine, 500mg/kg, 14-day orally administration of sulfasalazine + 7-day 4% DSS exposure from day 8 ). According to the results, the LP-A group, especially the LP-A-H group has significantly increased the length of mice colon, reduced the mice serum levels of pro-inflammatory cytokines, and increased seurm levels of antiinflammatory cytokines. In the histopathological observation of mice colon tissues, congestion and cell infiltration were alleviated, and the goblet cells were increased by the LP-A treatment. Based on the results presented above, this study will lay a certain theoretical foundation for the development of probiotic strain with the effect of preventing colitis.

Paper Citation

in Harvard Style

Zhou X. (2022). Preventive Effect of Lactobacillus Plantarum Isolated from Altay Traditional Fermented Yogurt on DSS-induced Colitis in Mice. In Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB, ISBN 978-989-758-595-1, pages 968-972. DOI: 10.5220/0011374800003443

in Bibtex Style

@conference{icbeb22,
author={Xin Zhou},
title={Preventive Effect of Lactobacillus Plantarum Isolated from Altay Traditional Fermented Yogurt on DSS-induced Colitis in Mice},
booktitle={Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,},
year={2022},
pages={968-972},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0011374800003443},
isbn={978-989-758-595-1},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,
TI - Preventive Effect of Lactobacillus Plantarum Isolated from Altay Traditional Fermented Yogurt on DSS-induced Colitis in Mice
SN - 978-989-758-595-1
AU - Zhou X.
PY - 2022
SP - 968
EP - 972
DO - 10.5220/0011374800003443