Based on the Transcriptome Study of the Effect of Sanyeqing Active Ingredients on Liver Cancer and the Impact of Resveratrol on MAPK3 and PRKCD

Yuexing Ma, Yuexing Ma, Yuexing Ma, Zhixin Zhu, Zhixin Zhu, Zhixin Zhu, Yaqiong Deng, Yaqiong Deng, Yaqiong Deng, Wei Xu, Wei Xu, Wei Xu, Zirong Peng, Zirong Peng, Zirong Peng, Rongbin Pan, Rongbin Pan, Feng Zhou, Feng Zhou, Feng Zhou, Huiming Hu, Huiming Hu, Huiming Hu, Xiaoqi Meng, Xiaoqi Meng, Xiaoqi Meng, Xin Qiao, Xuening Huang, Mengyu Hou

2022

Abstract

Tetrastigmatis hemsleyani (Sanyeqing) has pharmacological effects such as clearing away heat and detoxifying, anti-tumor, and regulating immunity. This research is dedicated to discovering and verifying the impact of Sanyeqing on liver cancer. Download the practical components and corresponding targets in Sanyeqing and liver cancer-related genes, and take the intersection of the two. Perform enrichment analysis and related gene interaction network analysis on the intersection genes. Subsequently, the core genes and pivot genes were screened out by Cytoscape to select different indicators for the intersection genes. Carry out survival analysis, tumor differential expression analysis, and cancer cell visual summary of core genes and pivot genes, and screen out the two most critical genes for molecular docking with corresponding active ingredients. The KEGG analysis results enriched the final two genes with the highest-ranking pathways and TIMER data tumor immune assessment. After the gene and the target were crossed, 131 crossed genes were obtained. The subsequent screening got 38 core genes and 20 pivot genes, and finally, the two most critical genes of MAPK3 and PRKCD were comprehensively screened through survival analysis. Resveratrol, the main chemical component, affects MAPK3 and PRKCD, and the docking results show that there is an effect between the two. The tumor immune assessment results also indicate that MAPK3 and PRKCD are expressed differently in normal tissues. Resveratrol has a particular effect on MAPK3 and PRKCD, which may have new thinking for treating liver cancer in the future.

Paper Citation

in Harvard Style

Ma Y., Zhu Z., Deng Y., Xu W., Peng Z., Pan R., Zhou F., Hu H., Meng X., Qiao X., Huang X. and Hou M. (2022). Based on the Transcriptome Study of the Effect of Sanyeqing Active Ingredients on Liver Cancer and the Impact of Resveratrol on MAPK3 and PRKCD. In Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB, ISBN 978-989-758-595-1, pages 1041-1050. DOI: 10.5220/0011376900003443

in Bibtex Style

@conference{icbeb22,
author={Yuexing Ma and Zhixin Zhu and Yaqiong Deng and Wei Xu and Zirong Peng and Rongbin Pan and Feng Zhou and Huiming Hu and Xiaoqi Meng and Xin Qiao and Xuening Huang and Mengyu Hou},
title={Based on the Transcriptome Study of the Effect of Sanyeqing Active Ingredients on Liver Cancer and the Impact of Resveratrol on MAPK3 and PRKCD},
booktitle={Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,},
year={2022},
pages={1041-1050},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0011376900003443},
isbn={978-989-758-595-1},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,
TI - Based on the Transcriptome Study of the Effect of Sanyeqing Active Ingredients on Liver Cancer and the Impact of Resveratrol on MAPK3 and PRKCD
SN - 978-989-758-595-1
AU - Ma Y.
AU - Zhu Z.
AU - Deng Y.
AU - Xu W.
AU - Peng Z.
AU - Pan R.
AU - Zhou F.
AU - Hu H.
AU - Meng X.
AU - Qiao X.
AU - Huang X.
AU - Hou M.
PY - 2022
SP - 1041
EP - 1050
DO - 10.5220/0011376900003443