Transcriptional Changes of Genes Linked to Alzheimer’s Disease

Wanning He

2022

Abstract

Alzheimer’s disease is a pogressive neurodegenerative disease that constitutes most cases of dementia. This study aims to converge existing data from GWAS studies and bulk RNA-Seq from patients with and without Alzheimer’s disease to prioritize genes involved in the disease pathology. For this study, I examine existing bulk RNA-Seq datasets from patients with and without Alzheimer’s disease [GSE159699], focusing on genes previously identified as links to late-onset Alzheimer’s disease in GWAS studies. I confirmed my results with a publicly available AD transcriptomics consensus tool published by the Swarup lab. In my analysis, I identified shared gene expression differences in STAG3L5P, MEF2C, MS4A6A, PILRA and CASS4 between Alzheimer’s disease and control patients across several datasets. These genes were previously linked to late-onset Alzheimer’s disease. Further investigation should explore how their mutations and gene expression differences contribute to the mechanisms underlying Alzheimer’s disease.

Paper Citation

in Harvard Style

He W. (2022). Transcriptional Changes of Genes Linked to Alzheimer’s Disease. In Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB, ISBN 978-989-758-595-1, pages 1112-1118. DOI: 10.5220/0011378300003443

in Bibtex Style

@conference{icbeb22,
author={Wanning He},
title={Transcriptional Changes of Genes Linked to Alzheimer’s Disease},
booktitle={Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,},
year={2022},
pages={1112-1118},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0011378300003443},
isbn={978-989-758-595-1},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,
TI - Transcriptional Changes of Genes Linked to Alzheimer’s Disease
SN - 978-989-758-595-1
AU - He W.
PY - 2022
SP - 1112
EP - 1118
DO - 10.5220/0011378300003443