Advance in Genome Editing of HIV-1 through CRISPR Technique

Jiaqi Liu

2022

Abstract

Although tons of great efforts and improvement have been made to treat HIV-1 patients, HIV-1/AIDS remain a big threat to global health. Although antiretroviral treatment (AT) yielded outstanding results in terms of its impressive effect in the suppression of HIV-1 replication and expression, latent viral reservoirs in HIV-1 patients still exist and potentially activate to disrupt human health in the future. Recent advance in the clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated nuclease 9 (Cas9) system has been well-engineered with finely designed single-guide RNA (sgRNA) to effectively target cellular co-receptors CCR5 and CXCR4 or HIV-1 genome so that this genomic editing system can reduce HIV-1 reduction and eradicate integrated provirus. Such a versatile genome editing technology has been applied to several types of human cells or animal models to testify its value in the prevention of HIV-1. Here, the progress of the CRISPR/Cas9 -based approach in recent decades will be covered and discussed. In addition, its potential drawbacks are also analyzed for future perspectives of its full application in the HIV-1 treatment regimen.

Paper Citation

in Harvard Style

Liu J. (2022). Advance in Genome Editing of HIV-1 through CRISPR Technique. In Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB, ISBN 978-989-758-595-1, pages 1131-1137. DOI: 10.5220/0011378700003443

in Bibtex Style

@conference{icbeb22,
author={Jiaqi Liu},
title={Advance in Genome Editing of HIV-1 through CRISPR Technique},
booktitle={Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,},
year={2022},
pages={1131-1137},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0011378700003443},
isbn={978-989-758-595-1},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,
TI - Advance in Genome Editing of HIV-1 through CRISPR Technique
SN - 978-989-758-595-1
AU - Liu J.
PY - 2022
SP - 1131
EP - 1137
DO - 10.5220/0011378700003443