Granger Causality Changes during Rt-fMRI Neurofeedback Training of Emotion Regulation for Insomnia Patients

Zhiyuan Feng, Hui Gao, Zhonglin Li, Linyuan Wang, Chi Zhang, Yan Bin, Li Tong

2022

Abstract

The amygdala is a key brain region in the emotional network. Studies have shown that emotion regulation neurofeedback training targeting amygdala based on real-time functional magnetic resonance can effectively improve the symptoms of insomnia patients. However, the brain mechanism for this improvement remains unclear. In this paper, Granger causality model was constructed to analyze the difference of causality between different brain regions before and after neurofeedback training. Firstly, the brain regions related to emotion regulation with significant differences in ReHo before and after neurofeedback training were selected as regions of interest. Secondly, the time series of the regions of interest were extracted to establish the Granger causality model. Finally, through group level analysis, the difference of effective connection before and after neurofeedback training was used as a biomarker to evaluate the effect of emotion regulation. The results have shown that rt-fMRI neurofeedback training targeting the amygdala significantly regulated the activity of brain regions related to emotion regulation in insomnia patients. And the effective connections from the right triangle inferior frontal gyrus to the left amygdala, the left precuneus to the left middle frontal gyrus, and the right middle cingulate gyrus to the left middle frontal gyrus were significantly enhanced. While the effective connection from the left middle frontal gyrus to the left precuneus was significantly reduced. Moreover, these changes were consistent with the scale evaluation results and clinical psychiatric studies, which further demonstrated that real-time fMRI neurofeedback training can change the effective connectivity of brain regions related to emotion regulation, and these changes could be used as a potential biomarker to evaluate the effect of neurofeedback training.

Paper Citation

in Harvard Style

Feng Z., Gao H., Li Z., Wang L., Zhang C., Bin Y. and Tong L. (2022). Granger Causality Changes during Rt-fMRI Neurofeedback Training of Emotion Regulation for Insomnia Patients. In Proceedings of the 1st International Conference on Health Big Data and Intelligent Healthcare - Volume 1: ICHIH, ISBN 978-989-758-596-8, pages 577-583. DOI: 10.5220/0011387300003438

in Bibtex Style

@conference{ichih22,
author={Zhiyuan Feng and Hui Gao and Zhonglin Li and Linyuan Wang and Chi Zhang and Yan Bin and Li Tong},
title={Granger Causality Changes during Rt-fMRI Neurofeedback Training of Emotion Regulation for Insomnia Patients},
booktitle={Proceedings of the 1st International Conference on Health Big Data and Intelligent Healthcare - Volume 1: ICHIH,},
year={2022},
pages={577-583},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0011387300003438},
isbn={978-989-758-596-8},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st International Conference on Health Big Data and Intelligent Healthcare - Volume 1: ICHIH,
TI - Granger Causality Changes during Rt-fMRI Neurofeedback Training of Emotion Regulation for Insomnia Patients
SN - 978-989-758-596-8
AU - Feng Z.
AU - Gao H.
AU - Li Z.
AU - Wang L.
AU - Zhang C.
AU - Bin Y.
AU - Tong L.
PY - 2022
SP - 577
EP - 583
DO - 10.5220/0011387300003438