Glutathione in Mental Disorders: Mechanisms and Therapies

Yawei Liang

2022

Abstract

In recent decades, topics related to mental diseases have gradually become important, and the treatments for mental diseases have also attracted attention from increasing number of researchers. Research directions have been focused on glutathione metabolism and oxidative stress. Appreciable number of reports have suggested that the content of reduced glutathione in patients with mental diseases, including Alzheimer’s disease, depression, anxiety disorder, autism, bipolar disorder and schizophrenia, is lower than that in normal people, suggesting that the dysregulation of glutathione redox may be one of leading the pathogeneses of these mental diseases. Regulation of glutathione metabolism involves many enzymes, such as GPx1 and GST, which have been comprehensively analyzed in this paper. Additionally, the potential of targeting glutathione metabolism balance as a breakthrough point for the treatment of psychiatric disorders will be discussed, listing some reported that have proven therapeutic effects of N-Acetyl-L-cysteine (NAC), minocycline and dimethyl fumarate (DMF) on mental disorders as well as their further therapeutic potential. The general purpose of this paper aims to study the recent progress focusing on glutathione metabolism in mental disorders mechanism and treatment, highlighting that GSH redox problems for mental illness is indispensable and outlook the potential development of treatments for mental disorders that target glutathione metabolism.

Paper Citation

in Harvard Style

Liang Y. (2022). Glutathione in Mental Disorders: Mechanisms and Therapies. In Proceedings of the 1st International Conference on Food Science and Biotechnology - Volume 1: FSB; ISBN 978-989-758-638-5, SciTePress, pages 18-25. DOI: 10.5220/0012000800003625

in Bibtex Style

@conference{fsb22,
author={Yawei Liang},
title={Glutathione in Mental Disorders: Mechanisms and Therapies},
booktitle={Proceedings of the 1st International Conference on Food Science and Biotechnology - Volume 1: FSB},
year={2022},
pages={18-25},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0012000800003625},
isbn={978-989-758-638-5},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st International Conference on Food Science and Biotechnology - Volume 1: FSB
TI - Glutathione in Mental Disorders: Mechanisms and Therapies
SN - 978-989-758-638-5
AU - Liang Y.
PY - 2022
SP - 18
EP - 25
DO - 10.5220/0012000800003625
PB - SciTePress