Formulation and Evaluation of Inhalable Porous Tobramycin Powder Prepared by Spray Drying Technology

Tianxiong Xu, Hao Miao, Renjie Li, Daoyin Liu, Zhenbo Tong

2022

Abstract

Inhaled tobramycin is one of the ideal ways to treat cystic fibrosis. The main purpose of this work is to prepare inhaled tobramycin dry powder by spray drying through reasonable formula design. The properties of the engineering particles are then characterized to reveal the particle-forming mechanism and structure-activity relationship. Tobramycin, which exists in the form of sulphate, has higher stability compared with its preparation alone. Leucine is enriched and crystallized on the surface of particles, which inhibits the absorption of environmental water by forming a hydrophobic shell and reduces the cohesion between particles. Compared with the organic solvent, ammonium bicarbonate (AB) as a porogen is less toxic and more suitable for scale-up. An optimized formulation was obtained when active pharmaceutical ingredient (API): Leucine: AB = 20: 7: 19. The sample under this formula has a porosity of 78.93 %. The loose and porous structure brings good flowability (CI index is 24.63 ± 1.17 %) and 40.78 % fine particles fraction (FPF). The particle deposition performance has been significantly improved. The drug load reaches 74.1 %, which adapts to the requirement of high-dose delivery of antibiotics.

Paper Citation

in Harvard Style

Xu T., Miao H., Li R., Liu D. and Tong Z. (2022). Formulation and Evaluation of Inhalable Porous Tobramycin Powder Prepared by Spray Drying Technology. In Proceedings of the 1st International Conference on Food Science and Biotechnology - Volume 1: FSB; ISBN 978-989-758-638-5, SciTePress, pages 42-46. DOI: 10.5220/0012001200003625

in Bibtex Style

@conference{fsb22,
author={Tianxiong Xu and Hao Miao and Renjie Li and Daoyin Liu and Zhenbo Tong},
title={Formulation and Evaluation of Inhalable Porous Tobramycin Powder Prepared by Spray Drying Technology},
booktitle={Proceedings of the 1st International Conference on Food Science and Biotechnology - Volume 1: FSB},
year={2022},
pages={42-46},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0012001200003625},
isbn={978-989-758-638-5},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st International Conference on Food Science and Biotechnology - Volume 1: FSB
TI - Formulation and Evaluation of Inhalable Porous Tobramycin Powder Prepared by Spray Drying Technology
SN - 978-989-758-638-5
AU - Xu T.
AU - Miao H.
AU - Li R.
AU - Liu D.
AU - Tong Z.
PY - 2022
SP - 42
EP - 46
DO - 10.5220/0012001200003625
PB - SciTePress