Hepatoprotective Effect of Niclosamide on Paracetamol-Induced Liver Toxicity in Rats

Ali Roshdy, Ismail A. Youssef

2022

Abstract

Liver diseases is considered one of the leading causes of death and an important barrier to increasing life expectancy. From among, liver fibrosis which is a result of a chronic damage to the liver leading to liver cirrhosis. Niclosamide is a potent anti-helminthic drug which has been used in treating the tapeworm infections. It also showed a hepatoprotective effect in induced liver toxicity models. The present study was conducted to identify the hepatoprotective effect of niclosamide in a paracetamol-induced liver toxicity. Rats were divided into five groups (6 rats per group): control group, disease group, 5 mg niclosamide group, 10 mg niclosamide group and 15 mg niclosamide group. Three doses of niclosamide (5 mg/kg, 10 mg/kg and 15 mg/kg) were injected intraperitoneal (i.p) for 4 weeks. Assessments included hepatic enzymes (AST, ALT, ALP and GGT), oxidative stress (MDA, GSH and SOD) and inflammatory markers (IL-6, TNF- α and NF-kB). The three doses of niclosamide (5 mg/kg, 10 mg/kg and 15 mg/kg) had significantly reduced the hepatic enzymes with the prominent effect at dose 15 mg/kg. There was also a significant decrease in the MDA activity, while significant increase in the GSH and SOD activity. Moreover, there was significant reduction in the levels of IL-6, TNF- α and NF-kB with the use of niclosamide (5 mg/kg, 10 mg/kg and 15 mg/kg). Therefore, in the current study, it presents the niclosamide as a promising hepatoprotective agent.

Paper Citation

in Harvard Style

Roshdy A. and A. Youssef I. (2022). Hepatoprotective Effect of Niclosamide on Paracetamol-Induced Liver Toxicity in Rats. In Proceedings of the 4th International Conference on Biotechnology and Biomedicine - Volume 1: ICBB; ISBN 978-989-758-637-8, SciTePress, pages 61-68. DOI: 10.5220/0012013200003633

in Bibtex Style

@conference{icbb22,
author={Ali Roshdy and Ismail A. Youssef},
title={Hepatoprotective Effect of Niclosamide on Paracetamol-Induced Liver Toxicity in Rats},
booktitle={Proceedings of the 4th International Conference on Biotechnology and Biomedicine - Volume 1: ICBB},
year={2022},
pages={61-68},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0012013200003633},
isbn={978-989-758-637-8},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 4th International Conference on Biotechnology and Biomedicine - Volume 1: ICBB
TI - Hepatoprotective Effect of Niclosamide on Paracetamol-Induced Liver Toxicity in Rats
SN - 978-989-758-637-8
AU - Roshdy A.
AU - A. Youssef I.
PY - 2022
SP - 61
EP - 68
DO - 10.5220/0012013200003633
PB - SciTePress