A Potentially Efficacious Approach for Treating HBV Viremia Using Combinatorial Cocktail Treatment

Yifei Hu, Junqing Yang, Haotian Zhou

2022

Abstract

Hepatitis B is one of the most prevalent diseases in the world and it covers a large population across the globe. The main cause–hepatitis B virus (HBV) has been studied for over 50 years. It targets hepatocytes and utilizes multiple mechanisms to replicate, survive and can cause acute or chronic infection. HBV viremia causes the impairment of T cell function which is a hallmark of chronic infection, making it an intractable virus to eliminate. Currently, common treatments for HBV viremia are using immunomodulatory agents such as nucleoside analogues. However, these drugs only suppress viral protein production and viral replication. HBsAg (hepatitis B surface antigen) remains on a certain level in serum and thereby the risk of hepatocellular carcinoma cannot be eradicated. In this study, we mainly review 3 pieces of researches, each of which introduces novel immunotherapy for chronic infection of HBV. And we hypothesize that the combinatorial treatment would potentially increase the efficacy for treating HBV viremia by increasing the number of HBV-specific CD8 T cells and would enhance the HBV-specific T cell functions, and further suppress the chronic infection.

Paper Citation

in Harvard Style

Hu Y., Yang J. and Zhou H. (2022). A Potentially Efficacious Approach for Treating HBV Viremia Using Combinatorial Cocktail Treatment. In Proceedings of the 4th International Conference on Biotechnology and Biomedicine - Volume 1: ICBB; ISBN 978-989-758-637-8, SciTePress, pages 97-103. DOI: 10.5220/0012014000003633

in Bibtex Style

@conference{icbb22,
author={Yifei Hu and Junqing Yang and Haotian Zhou},
title={A Potentially Efficacious Approach for Treating HBV Viremia Using Combinatorial Cocktail Treatment},
booktitle={Proceedings of the 4th International Conference on Biotechnology and Biomedicine - Volume 1: ICBB},
year={2022},
pages={97-103},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0012014000003633},
isbn={978-989-758-637-8},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 4th International Conference on Biotechnology and Biomedicine - Volume 1: ICBB
TI - A Potentially Efficacious Approach for Treating HBV Viremia Using Combinatorial Cocktail Treatment
SN - 978-989-758-637-8
AU - Hu Y.
AU - Yang J.
AU - Zhou H.
PY - 2022
SP - 97
EP - 103
DO - 10.5220/0012014000003633
PB - SciTePress