Combination Therapies Increase the Efficacy of Melanoma Treatment with Reduced Side Effects

Haoming Zhang, Jiayi Zong, Jingyi Guo, Lawrence Ma, Yijia Chen, Zhaojun Qiu

2022

Abstract

T Immunotherapy is found to have a promising effect on cancer treatment. It initiates activation of the immune response to fight against cancer. Previous studies have demonstrated that immune checkpoint inhibitors (ICIs), kinase inhibitors, and oncolytic viruses (OV) are possible cancer immunotherapies. Immune checkpoint inhibitors targeting programmed cell death-1 (PD-1) and programmed death-ligand 1 (PD-L1) have achieved great success in cancer immunotherapy. We hypothesized that utilizing anti-PD-1 antibodies, mitogen-activated protein kinase (MAPK) inhibitors, and oncolytic virus (T-VEC) could boost the efficacy of traditional PD-1 therapy towards melanoma, while the side effects can be alleviated with the supplement of anti-cytokine antibodies and anti-inflammatory drugs. A series of experiments were designed to be conducted in melanoma murine models. Expected outcomes of this combination therapy include enhanced tumor regression, extended survival, and mitigated side effects. The success of this study could bring up a new strategy for melanoma therapies.

Paper Citation

in Harvard Style

Zhang H., Zong J., Guo J., Ma L., Chen Y. and Qiu Z. (2022). Combination Therapies Increase the Efficacy of Melanoma Treatment with Reduced Side Effects. In Proceedings of the 4th International Conference on Biotechnology and Biomedicine - Volume 1: ICBB; ISBN 978-989-758-637-8, SciTePress, pages 104-115. DOI: 10.5220/0012014600003633

in Bibtex Style

@conference{icbb22,
author={Haoming Zhang and Jiayi Zong and Jingyi Guo and Lawrence Ma and Yijia Chen and Zhaojun Qiu},
title={Combination Therapies Increase the Efficacy of Melanoma Treatment with Reduced Side Effects},
booktitle={Proceedings of the 4th International Conference on Biotechnology and Biomedicine - Volume 1: ICBB},
year={2022},
pages={104-115},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0012014600003633},
isbn={978-989-758-637-8},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 4th International Conference on Biotechnology and Biomedicine - Volume 1: ICBB
TI - Combination Therapies Increase the Efficacy of Melanoma Treatment with Reduced Side Effects
SN - 978-989-758-637-8
AU - Zhang H.
AU - Zong J.
AU - Guo J.
AU - Ma L.
AU - Chen Y.
AU - Qiu Z.
PY - 2022
SP - 104
EP - 115
DO - 10.5220/0012014600003633
PB - SciTePress