Cancer Immunology: CAR T-Cell Therapy on Renal Cell Carcinoma

Qingyang Huang, Song Ying

2022

Abstract

Chimeric antigen receptor T (CAR-T) cell therapy is a revolutionary tool for cancer treatment. Studies have shown its potential in treating hematological malignancies. Renal cell carcinoma (RCC) as the most common kidney cancer, would develop malignant tumor in the lining of kidney tubules. It has the highest mortality rate among all genitourinary cancers. The main issue for RCC is its recurrence rate after surgery treatment. As CAR T-cell therapy has shown its benefits in treating the leukemia and lymphomas, its use in RCC is taking in consideration to reduce the chance of recurrence. Currently, there are some clinical trials are ongoing to measure its feasibility. It is also important to pay attention to the CAR T-cell associated toxicities, on-target off-tumor effect and tumor infiltration that would affect CAR T-cell therapy during the clinical trials. This review focused on presenting ongoing clinical trials of CAR T cell on RCC and its limitations. Some future perspectives are introduced to provide goals in later research.

Paper Citation

in Harvard Style

Huang Q. and Ying S. (2022). Cancer Immunology: CAR T-Cell Therapy on Renal Cell Carcinoma. In Proceedings of the 4th International Conference on Biotechnology and Biomedicine - Volume 1: ICBB; ISBN 978-989-758-637-8, SciTePress, pages 171-177. DOI: 10.5220/0012015600003633

in Bibtex Style

@conference{icbb22,
author={Qingyang Huang and Song Ying},
title={Cancer Immunology: CAR T-Cell Therapy on Renal Cell Carcinoma},
booktitle={Proceedings of the 4th International Conference on Biotechnology and Biomedicine - Volume 1: ICBB},
year={2022},
pages={171-177},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0012015600003633},
isbn={978-989-758-637-8},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 4th International Conference on Biotechnology and Biomedicine - Volume 1: ICBB
TI - Cancer Immunology: CAR T-Cell Therapy on Renal Cell Carcinoma
SN - 978-989-758-637-8
AU - Huang Q.
AU - Ying S.
PY - 2022
SP - 171
EP - 177
DO - 10.5220/0012015600003633
PB - SciTePress