Research and Application of CRISPR/Cas9 Technology in Oncology and Blood Diseases

Hengyi Zhang

2022

Abstract

The CRISPR/Cas system has been widely studied and applied to various fields as an efficient and simple gene editing tool. So far, CRISPR/Cas9 systems have evolved from the initial Cas9 to a variety of systems such as 12a and 13a; and also from the initial targeting of DNA and RNA to transcriptional regulation and DNA recycling. In addition, with the recognition of target sequences, certain CRISPR/Cas systems, such as Cas12, Cas13, and Cas14 proteins, exhibit non-specific cleavage activity on other single-stranded DNA or RNA molecules indirectly after the recognition of target sequences to initiate targeted cleavage activity under the guidance of guide RNA. This paper introduces the principle of CRISPR/Cas9 and discusses its application in oncology and hematological diseases, laying the foundation for the application of CRISPR/Cas9 technology in diseases, which also shows that CRISPR/Cas9 has a vast prospect of development.

Paper Citation

in Harvard Style

Zhang H. (2022). Research and Application of CRISPR/Cas9 Technology in Oncology and Blood Diseases. In Proceedings of the 4th International Conference on Biotechnology and Biomedicine - Volume 1: ICBB; ISBN 978-989-758-637-8, SciTePress, pages 204-208. DOI: 10.5220/0012018400003633

in Bibtex Style

@conference{icbb22,
author={Hengyi Zhang},
title={Research and Application of CRISPR/Cas9 Technology in Oncology and Blood Diseases},
booktitle={Proceedings of the 4th International Conference on Biotechnology and Biomedicine - Volume 1: ICBB},
year={2022},
pages={204-208},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0012018400003633},
isbn={978-989-758-637-8},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 4th International Conference on Biotechnology and Biomedicine - Volume 1: ICBB
TI - Research and Application of CRISPR/Cas9 Technology in Oncology and Blood Diseases
SN - 978-989-758-637-8
AU - Zhang H.
PY - 2022
SP - 204
EP - 208
DO - 10.5220/0012018400003633
PB - SciTePress