Mechanisms of Resistance to Cancer Immunotherapy

Sitong Zhao

2022

Abstract

Cancer immunotherapy has taken center stage in recent years as it can elicit a long-lasting anti-cancer response. However, the response rates are not consistently high in every patient. The majority of cancers still develop resistance to immunotherapy ranging from tumor intrinsic, microenvironment associated or host-related pathways. These include aberrant neoantigen presentation/processing, over-activation of tumor-cell-intrinsic signaling pathways, aberrant epigenetic regulation, presence of immunosuppressive cells, cytokines and chemokines, overexpression of multiple immune checkpoints and composition of gut bacteria. This review will focus on understanding the resistance mechanisms to immunotherapy in cancer and discuss ways to overcome this.

Paper Citation

in Harvard Style

Zhao S. (2022). Mechanisms of Resistance to Cancer Immunotherapy. In Proceedings of the 4th International Conference on Biotechnology and Biomedicine - Volume 1: ICBB; ISBN 978-989-758-637-8, SciTePress, pages 352-369. DOI: 10.5220/0012021000003633

in Bibtex Style

@conference{icbb22,
author={Sitong Zhao},
title={Mechanisms of Resistance to Cancer Immunotherapy},
booktitle={Proceedings of the 4th International Conference on Biotechnology and Biomedicine - Volume 1: ICBB},
year={2022},
pages={352-369},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0012021000003633},
isbn={978-989-758-637-8},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 4th International Conference on Biotechnology and Biomedicine - Volume 1: ICBB
TI - Mechanisms of Resistance to Cancer Immunotherapy
SN - 978-989-758-637-8
AU - Zhao S.
PY - 2022
SP - 352
EP - 369
DO - 10.5220/0012021000003633
PB - SciTePress