Design of Targeted and Release Controlled Liposome for Paclitaxel and Doxorubicin Combination in Breast Cancer Therapy

Chengpei Ouyang, Qi Zhu, Yifan Liu, Xiangqi Meng

2022

Abstract

Paclitaxel and doxorubicin are commonly used in chemotherapy of breast cancer. Now we have developed a kind of nanocarrier liposome that can deliver the combination of Dox and PTX to alleviate the pain brought by side effects and decrease the resistance. In this paper, we expected the result data of the drug loading capacity and the drug loading efficiency, the release of PTX and Dox in different pH environment, and the absorption of drugs which is estimated by the amount of free drug remains in the cells. The combination of Dox and PTX in liposome was modified with folic acid for tumor targeting, and achieved pH responsive drug release in tumor cell by introduction of N-(4-carboxybenzyl)-N, N-dimethyl-2,3-bis (oleoyloxy) propan-1-aminium (DOBAQ), a kind of pH sensitive lipid. The double layers were loaded with hydrophobic drug PTX, and the hydrophilic drug DOX is loaded in the aqueous core of the vesicle. We expected the results to reduce side effects and improve specificity when treating the cancer.

Paper Citation

in Harvard Style

Ouyang C., Zhu Q., Liu Y. and Meng X. (2022). Design of Targeted and Release Controlled Liposome for Paclitaxel and Doxorubicin Combination in Breast Cancer Therapy. In Proceedings of the 4th International Conference on Biotechnology and Biomedicine - Volume 1: ICBB; ISBN 978-989-758-637-8, SciTePress, pages 425-434. DOI: 10.5220/0012032000003633

in Bibtex Style

@conference{icbb22,
author={Chengpei Ouyang and Qi Zhu and Yifan Liu and Xiangqi Meng},
title={Design of Targeted and Release Controlled Liposome for Paclitaxel and Doxorubicin Combination in Breast Cancer Therapy},
booktitle={Proceedings of the 4th International Conference on Biotechnology and Biomedicine - Volume 1: ICBB},
year={2022},
pages={425-434},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0012032000003633},
isbn={978-989-758-637-8},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 4th International Conference on Biotechnology and Biomedicine - Volume 1: ICBB
TI - Design of Targeted and Release Controlled Liposome for Paclitaxel and Doxorubicin Combination in Breast Cancer Therapy
SN - 978-989-758-637-8
AU - Ouyang C.
AU - Zhu Q.
AU - Liu Y.
AU - Meng X.
PY - 2022
SP - 425
EP - 434
DO - 10.5220/0012032000003633
PB - SciTePress