Towards a Synthetic Tissue Model of the Lower Urinary Tract

Alexander Preis, Christina Merkl, Paula Miralles, Svenja Heer, Elisabeth Benke, Sebastian Reitelshöfer, Sina Martin, Ralf Rieker, Jörg Franke

2023

Abstract

The development of medical devices often depends on in vivo studies to validate the proper functioning of the products. These trials provide ethical as well as economic challenges, which can be partially addressed by the usage of realistic synthetic tissue models that replicate human anatomy and the corresponding properties of the biological tissue. In this work, a silicone-based model with a fiber structure and a PVA-based model that exhibits fabrication-induced anisotropy are presented in the special context of the lower urinary tract. The analysis of the materials in the uniaxial tensile test shows the anisotropic and viscoelastic properties of the materials. Furthermore, the anatomical model of the lower urinary tract shows expected deformation in simulation as well as in the real silicone model. Additionally, a suitable artificial urine according to ISO 20696 is shown for use with the model. First experiments to change the pH of the artificial urine are successfully conducted.

Paper Citation

in Harvard Style

Preis A., Merkl C., Miralles P., Heer S., Benke E., Reitelshöfer S., Martin S., Rieker R. and Franke J. (2023). Towards a Synthetic Tissue Model of the Lower Urinary Tract. In Proceedings of the 16th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2023) - Volume 1: BIODEVICES; ISBN 978-989-758-631-6, SciTePress, pages 190-197. DOI: 10.5220/0011780500003414

in Bibtex Style

@conference{biodevices23,
author={Alexander Preis and Christina Merkl and Paula Miralles and Svenja Heer and Elisabeth Benke and Sebastian Reitelshöfer and Sina Martin and Ralf Rieker and Jörg Franke},
title={Towards a Synthetic Tissue Model of the Lower Urinary Tract},
booktitle={Proceedings of the 16th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2023) - Volume 1: BIODEVICES},
year={2023},
pages={190-197},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0011780500003414},
isbn={978-989-758-631-6},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 16th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2023) - Volume 1: BIODEVICES
TI - Towards a Synthetic Tissue Model of the Lower Urinary Tract
SN - 978-989-758-631-6
AU - Preis A.
AU - Merkl C.
AU - Miralles P.
AU - Heer S.
AU - Benke E.
AU - Reitelshöfer S.
AU - Martin S.
AU - Rieker R.
AU - Franke J.
PY - 2023
SP - 190
EP - 197
DO - 10.5220/0011780500003414
PB - SciTePress