Parkinson and REM Sleep Behaviour Disorder: HRV Difference During Polysomnography

Parisa Sattar, Parisa Sattar, Parisa Sattar, Giulia Baldazzi, Nicla Mandas, Nicla Mandas, Elisa Casaglia, Michela Figorilli, Monica Puligheddu, Danilo Pani

2023

Abstract

Approximately 40% to 70% of patients affected by Parkinson’s disease (PD) suffer from autonomic dysfunction that could be related to REM sleep behavior disorder (RBD). In this work, polysomnographic recordings were analyzed to study heart rate variability (HRV) during different sleep stages in a cohort of 20 participants, ten with Parkinson Disease with RBD (RBDpd) and ten unaffected (CG). HRV analysis was performed by considering the first 5 min epoch from each stage (i.e., wake, N2, N3, and REM), including time and frequency domain indexes, and entropy measures. Statistical analysis was carried out to assess any possible significant difference between CG and RBDpd groups, but also between the wake and REM stages in each group. Significant differences of the combined effect of RBD and PD emerged in both time and frequency domains, but also when considering nonlinear parameters during REM and awake phases. Accordingly, a comparison of wake and REM phase showed significant differences in all HRV parameters for CG that was absent in the RBDpd group. Our findings reveal the potentiality of HRV as a digital biomarker for RBDpd, by indicating distinct dysfunction of both parasympathetic and sympathetic activities in the RBDpd group, partially in line with previous studies.

Paper Citation

in Harvard Style

Sattar P., Baldazzi G., Mandas N., Casaglia E., Figorilli M., Puligheddu M. and Pani D. (2023). Parkinson and REM Sleep Behaviour Disorder: HRV Difference During Polysomnography. In Proceedings of the 16th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2023) - Volume 4: BIOSIGNALS; ISBN 978-989-758-631-6, SciTePress, pages 366-370. DOI: 10.5220/0011838700003414

in Bibtex Style

@conference{biosignals23,
author={Parisa Sattar and Giulia Baldazzi and Nicla Mandas and Elisa Casaglia and Michela Figorilli and Monica Puligheddu and Danilo Pani},
title={Parkinson and REM Sleep Behaviour Disorder: HRV Difference During Polysomnography},
booktitle={Proceedings of the 16th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2023) - Volume 4: BIOSIGNALS},
year={2023},
pages={366-370},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0011838700003414},
isbn={978-989-758-631-6},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 16th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2023) - Volume 4: BIOSIGNALS
TI - Parkinson and REM Sleep Behaviour Disorder: HRV Difference During Polysomnography
SN - 978-989-758-631-6
AU - Sattar P.
AU - Baldazzi G.
AU - Mandas N.
AU - Casaglia E.
AU - Figorilli M.
AU - Puligheddu M.
AU - Pani D.
PY - 2023
SP - 366
EP - 370
DO - 10.5220/0011838700003414
PB - SciTePress