Modeling of Naïve Lymphocyte Signaling Pathway

Isaac Barjis, Aliyah Amin, Amber Barjis, Saif Amin

2023

Abstract

The immune system in general and T cells, in particular, play a critical role in protecting the organism from infection and repairing damaged tissue. T cells are not only key components of the immune system but are also central in mobilizing the adaptive immune responses at all stages of fighting infection. Furthermore, studies have shown that subsets of T helper cells are critical for the activation of antitumor responses. T cells have been intensively studied by both experimental immunologists and modelers. However, none of the research papers represent the complete process that will show the link between antigen-presenting cells, subtypes of T cells, and other signaling pathways. In this paper, we illustrate the first steps of an automation process for quantitative modeling, of the naïve T lymphocytes activation pathway by discrete modeling language using colored Petri nets (CPN). Modeling, simulation, and analyzing T cell activation signaling pathways will improve our understanding of the structure and dynamics of these pathways considerably. Petri nets have been proposed as an effective formalism for Systems Biology and modeling of metabolic pathways.

Paper Citation

in Harvard Style

Barjis I., Amin A., Barjis A. and Amin S. (2023). Modeling of Naïve Lymphocyte Signaling Pathway. In Proceedings of the 13th International Conference on Simulation and Modeling Methodologies, Technologies and Applications - Volume 1: SIMULTECH; ISBN 978-989-758-668-2, SciTePress, pages 385-392. DOI: 10.5220/0012127200003546

in Bibtex Style

@conference{simultech23,
author={Isaac Barjis and Aliyah Amin and Amber Barjis and Saif Amin},
title={Modeling of Naïve Lymphocyte Signaling Pathway},
booktitle={Proceedings of the 13th International Conference on Simulation and Modeling Methodologies, Technologies and Applications - Volume 1: SIMULTECH},
year={2023},
pages={385-392},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0012127200003546},
isbn={978-989-758-668-2},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 13th International Conference on Simulation and Modeling Methodologies, Technologies and Applications - Volume 1: SIMULTECH
TI - Modeling of Naïve Lymphocyte Signaling Pathway
SN - 978-989-758-668-2
AU - Barjis I.
AU - Amin A.
AU - Barjis A.
AU - Amin S.
PY - 2023
SP - 385
EP - 392
DO - 10.5220/0012127200003546
PB - SciTePress