An Event-Driven Closed-Loop Ultrasound Stimulator Composed of a Micro-Transducer and Multi-Site Electrodes in Vitro

Ryo Furukawa, Shuichi Murakami, Takashi Tateno

2024

Abstract

Ultrasound neuromodulation, in which local and deep brain areas are stimulated, holds promise for clinical applications. However, the mechanisms of action underlying the stimulation effects are still unknown. In vitro experiments are helpful for investigating the stimulation mechanisms because they allow easy control of extracellular conditions. Compared with closed-loop systems, conventional open-loop systems do not permit monitoring of neural activity, and thus can lead to excessive neural stimulation. In this study, we developed a piezoelectric micromachined ultrasound transducer (PMUT) combined with monitoring microelectrodes. To examine the potential of our device as a neuromodulation tool, we measured the cellular responses to generated ultrasound stimulation. Subsequently, we constructed a closed-loop system that combined our PMUT with monitoring electrodes, and applied event-related ultrasound stimulation to brain slices in vitro. We discuss future applications of a closed-loop ultrasound stimulation system.

Paper Citation

in Harvard Style

Furukawa R., Murakami S. and Tateno T. (2024). An Event-Driven Closed-Loop Ultrasound Stimulator Composed of a Micro-Transducer and Multi-Site Electrodes in Vitro. In Proceedings of the 17th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES; ISBN 978-989-758-688-0, SciTePress, pages 95-102. DOI: 10.5220/0012307900003657

in Bibtex Style

@conference{biodevices24,
author={Ryo Furukawa and Shuichi Murakami and Takashi Tateno},
title={An Event-Driven Closed-Loop Ultrasound Stimulator Composed of a Micro-Transducer and Multi-Site Electrodes in Vitro},
booktitle={Proceedings of the 17th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES},
year={2024},
pages={95-102},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0012307900003657},
isbn={978-989-758-688-0},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 17th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES
TI - An Event-Driven Closed-Loop Ultrasound Stimulator Composed of a Micro-Transducer and Multi-Site Electrodes in Vitro
SN - 978-989-758-688-0
AU - Furukawa R.
AU - Murakami S.
AU - Tateno T.
PY - 2024
SP - 95
EP - 102
DO - 10.5220/0012307900003657
PB - SciTePress