The Interactive Network Visualization of the Interactions Between Topologically Associating Domains in the Genome of Fruit Fly

Samira Mali, Swetha Annavarapu, Swetha Annavarapu

2024

Abstract

In this work, we created a network visualization to help you understand how Topologically Associating Domains (TADs) interact with each other across the genome based on where the TAD is located, whether it is near the center of the nucleus or near the edge of the nucleus. This visualization can reveal how the dense regions and sparse regions of chromosome interactions are distributed in one view. The pilot study demonstrates how network visualization of TAD-TAD interactions can quickly answer numerous major questions in 3D genome and epigenetics field without requiring the development of Machine Learning methods or Algorithms to unlock Heatmap structures. The questions include but are not limited to, determining many-way interactions and interactions between TADs belonging to various epigenetic classes.

Paper Citation

in Harvard Style

Mali S. and Annavarapu S. (2024). The Interactive Network Visualization of the Interactions Between Topologically Associating Domains in the Genome of Fruit Fly. In Proceedings of the 17th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIOINFORMATICS; ISBN 978-989-758-688-0, SciTePress, pages 504-511. DOI: 10.5220/0012456200003657

in Bibtex Style

@conference{bioinformatics24,
author={Samira Mali and Swetha Annavarapu},
title={The Interactive Network Visualization of the Interactions Between Topologically Associating Domains in the Genome of Fruit Fly},
booktitle={Proceedings of the 17th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIOINFORMATICS},
year={2024},
pages={504-511},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0012456200003657},
isbn={978-989-758-688-0},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 17th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIOINFORMATICS
TI - The Interactive Network Visualization of the Interactions Between Topologically Associating Domains in the Genome of Fruit Fly
SN - 978-989-758-688-0
AU - Mali S.
AU - Annavarapu S.
PY - 2024
SP - 504
EP - 511
DO - 10.5220/0012456200003657
PB - SciTePress