![](bg4.png)
The reverse J-shape association between BMI and the
adjusted hazard ratio of incident proteinuria was
observed. The nadir was approximately estimated
around 22 kg/m
2
as shown in figure 2. With subgroup
analyses, there was no difference according to sex and
age (sex-specific median age; 44 years old in men, 49
years old in women).
Figure 3: The association between body mass index and
incident proteinuria in subgroups; A reverse J-shape
association between body mass index and the adjusted hazard
ratio of incident proteinuria was not differential according to
sex and age with adjustment for age, sex, smoking status,
regular exercise, regular alcohol consumption, known history
of diabetes or hypertension medication, systolic blood
pressure, fasting serum glucose, serum triglycerides, and serum
high-density lipoprotein-cholesterol at baseline. The shaded
area represents 95% confidence interval.
4 CONCLUSIONS
The association of BMI and eGFR was not linear and
differential according to sex and age. Between BMI
and incident proteinuria, the reverse J-shape
association was observed and its nadir between 22
and 23 kg/m
2
. It is necessary to consider non-linear
association of BMI and eGFR and incident
proteinuria when the association of obesity with renal
function or incident proteinuria is evaluated. Clinical
implications of these observations need to be studied
with future studies.
ACKNOWLEDGEMENTS
This research was supported by Next-Generation
Information Computing Development Program
through the National Research Foundation of Korea
(NRF) funded by the Ministry of Science, ICT (NRF-
2017M3C4A7083412). The National Health
Information Database made by the National Health
Insurance Service (NHIS) of Korea was used.
REFERENCES
Grubbs, V., Lin, F., Vittinghoff, E., Shlipak, M., et al. (2014).
Body Mass Index and Early Kidney Function Decline in
Young Adults: A Longitudinal Analysis of the CARDIA
(Coronary Artery Risk Development in Young Adults)
Study. American Journal of Kidney Diseases, 63(4),
pp.590-597.
Hobbs, H., Farmer, C., Irving, J., et al. (2011). Is high body
mass index independently associated with diminished
glomerular filtration rate? An Epidemiological study.
Journal of Renal Care, 37(3), pp.148-154.
Inker LA, Schmid CH, Tighiouart H, et al. (2012). Estimating
glomerular filtration rate from serum creatinine and
cystatin C. N Engl J Med.;367:20-29.
Li, K., Zou, J., Ye, Z., Di, J., et al. (2016). Effects of Bariatric
Surgery on Renal Function in Obese Patients: A Systematic
Review and Meta Analysis. PLOS ONE, 11(10),
p.e0163907.
Mahmoodnia, L. and Tamadon, M. (2017). On the occasion of
world kidney day 2017; obesity and its relationship with
chronic kidney disease. Journal of Nephropathology, 6(3),
pp.105-109.
Kawamoto, R., Kohara, K., Tabara, Y., Et Al. (2008). An
Association between Body Mass Index and Estimated
Glomerular Filtration Rate. Hypertension Research, 31(8),
pp.1559-1564.
Kansui, Y., Ohtsubo, T., Goto, K., et al. (2012). Association of
Body Mass Index with Glomerular Filtration Rate in
Japanese: A Cross-Sectional Study in Work-Site
Population. Clinical and Experimental Hypertension,
34(2), pp.140-144.
Cheol Seong, S., Kim, Y., Khang, Y., et al. (2016). Data
Resource Profile: The National Health Information
Database of the National Health Insurance Service in
South Korea. International Journal of Epidemiology,
p.dyw 253.
Sato, Y., Fujimoto, S., Konta, T., Iseki, K., et al. (2013). U-
shaped association between body mass index and
proteinuria in a large Japanese general population sample.
Clinical and Experimental Nephrology, 18(1), pp.75-86.
Jang, C., Hyun, Y., Lee, K. and Kim, H. (2014). The
association between underweight and the development of
albuminuria is different between sexes in relatively healthy
Korean subjects. Nephrology Dialysis Transplantation,
29(11), pp.2106-2113.
HEALTHINF 2018 - 11th International Conference on Health Informatics
590