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and 1.82 ± 0.05 µg/mL respectively.The cytotoxicity
estimate of natural product is related to content of
active compound in these plants including Vernonia
amygdalina Del. Flavonoids and
triterpenoids/steroids estimated as active compounds
(Yadav, et al., 2012; Igile, et al., 1994; Quassie, et
al., 2016). Doxorubicin is one of chemotherapeutic
agent showed strong activity on T47D cell lines with
IC
50
value of 1.82 ± 0.05 µg/mL. T47D cells line
underwent resistant to doxorubicin pass through to
p53 mutation (Di Leo, et al., 2007; Vassade, et al.,
2005).
ACKNOWLEDGEMENTS
We gratefully thank to Directorate of Higher
Education, Ministry of Research Technology and
High Education, Indonesia through “Hibah
Penelitian Dasar Unggulan Perguruan Tinggi”
Research Grant 2018 for financial support in the
study.
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Evaluation of Antioxidant and Cytotoxic Activities of Vernonia amygdalina Del. Leaves
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