Study of Dipeptidil Peptidase 4 Inhibitors based on Molecular Docking Experiments

A. Saraiva, J. Soares, Nator Costa, José Sousa, N. Ferreira, Antonio Valente, Salviano Soares

Abstract

The lack of physical activity and poor nutrition triggers various diseases, among them is diabetes. In this context, several researches seek ways that can mitigate these diseases to provide a better quality of life for people. Therefore, the present work aims to analyze the possible inhibitors of the enzyme Dipeptidil Peptidase 4 that hypotheses will be stipulated for the creation of new drugs through molecular docking techniques, that is, a computational simulation of combinations of drugs of the family of gliptins with other antidiabetics (metformin, glyburide and cucurbitacin). Among the results, it was observed that the antidiabetic cucurbitacin combined with the gliptines obtained greater energy during the process.

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Paper Citation


in Harvard Style

Saraiva A., Soares J., Costa N., Sousa J., Ferreira N., Valente A. and Soares S. (2019). Study of Dipeptidil Peptidase 4 Inhibitors based on Molecular Docking Experiments.In Proceedings of the 12th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 3: BIOINFORMATICS, ISBN 978-989-758-353-7, pages 322-330. DOI: 10.5220/0007692203220330


in Bibtex Style

@conference{bioinformatics19,
author={A. Saraiva and J. Soares and Nator Costa and José Sousa and N. Ferreira and Antonio Valente and Salviano Soares},
title={Study of Dipeptidil Peptidase 4 Inhibitors based on Molecular Docking Experiments},
booktitle={Proceedings of the 12th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 3: BIOINFORMATICS,},
year={2019},
pages={322-330},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0007692203220330},
isbn={978-989-758-353-7},
}


in EndNote Style

TY - CONF

JO - Proceedings of the 12th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 3: BIOINFORMATICS,
TI - Study of Dipeptidil Peptidase 4 Inhibitors based on Molecular Docking Experiments
SN - 978-989-758-353-7
AU - Saraiva A.
AU - Soares J.
AU - Costa N.
AU - Sousa J.
AU - Ferreira N.
AU - Valente A.
AU - Soares S.
PY - 2019
SP - 322
EP - 330
DO - 10.5220/0007692203220330