BIOPHYSICAL MODEL OF A MUSCLE FATIGUE PROCESS INVOLVING Ca2+ RELEASE DYNAMICS UPON THE HIGH FREQUENCY ELECTRICAL STIMULATION

Piotr Kaczmarek

2008

Abstract

The aim of this study is to create a model which enables to explain the muscle fibre contraction due to various stimulation programs. The model accounts for Ca2+ release dynamics both as a result of an action potential and of a stimulus shape, duration and frequency. It has been assumed that the stimulus can directly activate the voltage-dependent receptors (dihydropiridine receptors) responsible for a Ca2+ release. The stimulation programs consisted of standard stimulation trains made of low and middle frequency square pulses. High frequency modulating harmonic signals have been tested to investigate the fibre fatigue effect. It has been observed that fatigue effect factors depend on the selected stimulation program. The results reveal that the fatigue effect could be minimized by changing the shape and frequency of the stimulation waveform. Such the model could be useful for a preliminary selection and optimization of the stimulus shape and the stimulation trains, thus reducing the number of in vivo experiments.

Paper Citation

in Harvard Style

Kaczmarek P. (2008). BIOPHYSICAL MODEL OF A MUSCLE FATIGUE PROCESS INVOLVING Ca2+ RELEASE DYNAMICS UPON THE HIGH FREQUENCY ELECTRICAL STIMULATION . In Proceedings of the First International Conference on Bio-inspired Systems and Signal Processing - Volume 2: BIOSIGNALS, (BIOSTEC 2008) ISBN 978-989-8111-18-0, pages 52-57. DOI: 10.5220/0001062300520057

in Bibtex Style

@conference{biosignals08,
author={Piotr Kaczmarek},
title={BIOPHYSICAL MODEL OF A MUSCLE FATIGUE PROCESS INVOLVING Ca2+ RELEASE DYNAMICS UPON THE HIGH FREQUENCY ELECTRICAL STIMULATION},
booktitle={Proceedings of the First International Conference on Bio-inspired Systems and Signal Processing - Volume 2: BIOSIGNALS, (BIOSTEC 2008)},
year={2008},
pages={52-57},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0001062300520057},
isbn={978-989-8111-18-0},
}

in EndNote Style

TY - CONF
JO - Proceedings of the First International Conference on Bio-inspired Systems and Signal Processing - Volume 2: BIOSIGNALS, (BIOSTEC 2008)
TI - BIOPHYSICAL MODEL OF A MUSCLE FATIGUE PROCESS INVOLVING Ca2+ RELEASE DYNAMICS UPON THE HIGH FREQUENCY ELECTRICAL STIMULATION
SN - 978-989-8111-18-0
AU - Kaczmarek P.
PY - 2008
SP - 52
EP - 57
DO - 10.5220/0001062300520057