ECG SIMULATION WITH IMPROVED MODEL OF CELL ACTION POTENTIALS

Roman Trobec, Matjaž Depolli, Viktor Avbelj

2009

Abstract

An improved model of action potentials (AP) is proposed to increase the accuracy of simulated electrocardiograms (ECGs). ECG simulator is based on a spatial model of a left ventricle, composed of cubic cells. Three distinct APs, modeled with functions proposed by Wohlfard, have been assigned to the cells, forming epicardial, mid, and endocardial layers. Identification of exact parameter values for AP models has been done through optimization of the simulated ECGs. Results have shown that only through an introduction of a minor extension to the AP model, simulator is able to produce realistic ECGs. The same extension also proves essential for achieving a good fit between the measured and modeled APs.

References

  1. Depolli, M., Avbelj, V., and Trobec, V. (2008). Computersimulated alternative modes of U-wave genesis. J Cardiovasc Electrophysiol, 19(1):84-89.
  2. Druin, E., Charpentier, F., Gauthier, C., Laurent, K., and Le Marec, H. (1995). Electrophysiologic characteristics of cells spanning the left ventricular wall of human heart: Evidence for presence of M cells. J Am Coll Cardiol, 26(1):185-192.
  3. Franz, M. (1996). Mechano-electrical feedback in ventricular myocardium. Cardiovasc Res, 32(1):15-24.
  4. Macfarlane, P. and Lawrie, T., editors (1989). Comprehensive Electrocardiology: Theory and Practice in Health and Disease, volume 1. Pergamon Press, New York, 1st edition.
  5. Miller, W. and Geselowitz, D. (1978). Simulation studies of the electrocardiogram. I. The normal heart. Circ Res, 43(2):301-315.
  6. Ritsema van Eck, H., Kors, J., and van Herpen, G. (2005). The U wave in the electrocardiogram: A solution for a 100-year-old riddle. Cardiovasc Res, 67(2):256-262.
  7. Surawicz, B. (1998). U wave: Facts, hypotheses, misconceptions, and misnomers. J Cardiovasc Electrophysiol, 9(10):1117-1128.
  8. Ten Tusscher, K., Noble, D., Noble, P., and Panfilov, A. (2004). A model for human ventricular tissue. Am J Physiol Heart Circ Physiol, 286(4):H1573-H1589.
  9. Watanabe, Y. (1975). Purkinje repolarization as a possible cause of the U wave in the electrocardiogram. Circulation, 51(6):1030-1037.
  10. Wohlfart, B. (1987). A simple model for demonstration of SST-changes in ECG. Eur Heart J, 8:409-416.
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Paper Citation


in Harvard Style

Trobec R., Depolli M. and Avbelj V. (2009). ECG SIMULATION WITH IMPROVED MODEL OF CELL ACTION POTENTIALS . In Proceedings of the International Conference on Health Informatics - Volume 1: HEALTHINF, (BIOSTEC 2009) ISBN 978-989-8111-63-0, pages 18-21. DOI: 10.5220/0001535400180021


in Bibtex Style

@conference{healthinf09,
author={Roman Trobec and Matjaž Depolli and Viktor Avbelj},
title={ECG SIMULATION WITH IMPROVED MODEL OF CELL ACTION POTENTIALS},
booktitle={Proceedings of the International Conference on Health Informatics - Volume 1: HEALTHINF, (BIOSTEC 2009)},
year={2009},
pages={18-21},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0001535400180021},
isbn={978-989-8111-63-0},
}


in EndNote Style

TY - CONF
JO - Proceedings of the International Conference on Health Informatics - Volume 1: HEALTHINF, (BIOSTEC 2009)
TI - ECG SIMULATION WITH IMPROVED MODEL OF CELL ACTION POTENTIALS
SN - 978-989-8111-63-0
AU - Trobec R.
AU - Depolli M.
AU - Avbelj V.
PY - 2009
SP - 18
EP - 21
DO - 10.5220/0001535400180021