DEVELOPMENT AND APPLICATION OF A ROACH GENE REGULATION PROFILE BASED GENDER DISCRIMINATION METHOD

Yongxiang Fang

2009

Abstract

This study extracted, from a roach gonad microarray data set, a gene regulation profile in contrast of male and female roaches. Then a method is developed to use this profile to discriminate the genders of the roaches involved in another roach microarray experiments in which the roaches are too young for their genders to be classifiable. The gender is an ignorable factor in roach gene expression study and the gender information is vital for the success of such a microarray study, because without the gender information the treatment effects could not be estimated correctly. A comparison of the analytical results of target data set based on with and without concerning the gender effects shows that the estimation of treatment effects is improved greatly when obtained gender information is incorporated in the data analysis. This is reversely evident that the roach gender discrimination method developed in this study performs very well.

References

  1. Benjamini, Y. and Hochberg, Y., 1995. Controlling the false discovery rate: A practical and powerful approach to multiple testing. J. Roy. Statist. Soc. Ser. B 57 289--300.
  2. Benjamini, Y. and Hochberg, Y., 2000. On the adaptive control of the false discovery rate in multiple testing with independent statistics. J. Educational and Behavioral Statistics 25 60--83.
  3. Cleveland, W.S. and Delvin, S.J., 1988. Locally weighted regression: An approach to regression analysis by local fitting. Journal of American Statistical Association, Vol. 83, pp. 596-610.
  4. Cleveland, W.S., 1979. Robust locally weighted regression and smoothing scatterplots. Journal of American Statistical Association, Vol. 74, pp. 829- 836.
  5. Gibson, R., Smith, M. D., Spary, C. J., Tyler, C. R., and Hill, E. M., 2005. Mixtures of estrogenic contaminants in bile of fish exposed to wastewater treatment works effluents. Environmental Science & Technology 39, 2461-2471.
  6. Huber, W., von Heydebreck, A., Sultmann, H., Poustka, A., Vingron, M., 2002. Variance stabilization applied to microarray data calibration and to the quantification of differential expression. Bioinformatics 18 (Suppl. 1), S96-S104.
  7. Jobling, S., Williams, R., Johnson, A., Taylor, A., GrossSorokin, M., Nolan, M., Tyler, C. R., van Aerle, R., Santos, E., and Brighty, G., 2006. Predicted exposures to steroid estrogens in U.K. rivers correlate with widespread sexual disruption in wild fish populations. Environmental Health Perspectives 114, 32-39.
  8. Katsu, Y., Lange, A., Urushitani, H., Ichikawa, R., Paull, G. C., Cahill, L. L., Jobling, S., Tyler, C. R., and Iguchi, T., 2007. Functional associations between two estrogen receptors, environmental estrogens, and sexual disruption in the roach (Rutilus rutilus). Environmental Science & Technology 41, 3368-3374.
  9. Schultz, H., 1996. Drastic decline of the proportion of males in the roach (Rutilus rutilus L.) population of Bautzen reservoir (Saxony, Germany): result of direct and indirect effects of biomanipulation. Limnologica 26, 153-164.
  10. Wit, E., Nobile, A., and Khanin, R., 2005. Near-optimal designs for dual-channel microarray studies. Applied Statistics 54, 817-830.
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Paper Citation


in Harvard Style

Fang Y. (2009). DEVELOPMENT AND APPLICATION OF A ROACH GENE REGULATION PROFILE BASED GENDER DISCRIMINATION METHOD . In Proceedings of the International Conference on Knowledge Discovery and Information Retrieval - Volume 1: KDIR, (IC3K 2009) ISBN 978-989-674-011-5, pages 263-269. DOI: 10.5220/0002275302630269


in Bibtex Style

@conference{kdir09,
author={Yongxiang Fang},
title={DEVELOPMENT AND APPLICATION OF A ROACH GENE REGULATION PROFILE BASED GENDER DISCRIMINATION METHOD},
booktitle={Proceedings of the International Conference on Knowledge Discovery and Information Retrieval - Volume 1: KDIR, (IC3K 2009)},
year={2009},
pages={263-269},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0002275302630269},
isbn={978-989-674-011-5},
}


in EndNote Style

TY - CONF
JO - Proceedings of the International Conference on Knowledge Discovery and Information Retrieval - Volume 1: KDIR, (IC3K 2009)
TI - DEVELOPMENT AND APPLICATION OF A ROACH GENE REGULATION PROFILE BASED GENDER DISCRIMINATION METHOD
SN - 978-989-674-011-5
AU - Fang Y.
PY - 2009
SP - 263
EP - 269
DO - 10.5220/0002275302630269