COMPUTER SIMULATION OF MICROELECTRODE BASED BIO-IMPEDANCE MEASUREMENTS WITH COMSOL

Alberto Olmo, Alberto Yúfera

2010

Abstract

Electrical models for microelectrode-cell interfaces are essential to match electrical simulations to real bio-systems performance and correctly to decode the results obtained experimentally. The accurate response simulation of a microelectrode sensor to changes in the cell-electrode system, such as cell growth, enables the optimum microelectrode design process. We report the use of COMSOL quasi-static mode, contrary to other DC modes frequently used, including magnetic fields to calculate the bioimpedance of the system. A fully electrode-cell model has been built, and the effect of fibroblasts of different diameters on the simulated impedance of small microelectrodes (32-µm square) has been studied, in order to validate the model and to characterize the microelectrode sensor response to changes in cell size and density.

References

  1. Beach, R.D. et al, 2005. Towards a Miniature In Vivo Telemetry Monitoring System Dynamically Configurable as a Potentiostat or Galvanostat for Twoand Three- Electrode Biosensors, IEEE Trans. On Instrumentation and Measurement, vol. 54, nº1, pp: 61-72, 2005.
  2. Yúfera, A. et al., 2005. A Tissue Impedance Measurement Chip for Myocardial Ischemia Detection. IEEE Transaction on Circuits and Systems: Part I. vol.52, nº:12 pp: 2620-2628.
  3. Radke, S.M and Alocilja, E.C., 2004. Design and Fabrication of a Microimpedance Biosensor for Bacterial Detection, IEEE Sensor Journal, vol. 4, nº 4, pp: 434-440.
  4. Borkholder, D. A., 1998. Cell-Based Biosensors Using Microelectrodes. PhD Thesis, Stanford University.
  5. Huang X. et al., 2004. Simulation of Microelectrode Impedance Changes Due to Cell Growth, IEEE Sensors Journal, vol.4, nº5, pp: 576-583.
  6. Yúfera A. et al., 2008. A Method for Bioimpedance Measure with Four- and Two-Electrode Sensor Systems, 30th Annual International IEEE EMBS Conference, pp: 2318-2321.
  7. Joye N. et al., 2008. An Electrical Model of the CellElectrode Interface for High-density Microelectrode Arrays, 30th Annual International IEEE EMBS Conference, pp: 559-562. 2008
  8. Giebel, K.F. et al., 1999. Imaging of cell/substrate contacts of living cells with surface plasmon resonance microscopy, Biophysics Journal, vol. 76, pp: 509-516.
  9. Geddes, L.A., 1972. Electrodes and the Measurement of the Bioelectrical Events, New York. Wiley.
Download


Paper Citation


in Harvard Style

Olmo A. and Yúfera A. (2010). COMPUTER SIMULATION OF MICROELECTRODE BASED BIO-IMPEDANCE MEASUREMENTS WITH COMSOL . In Proceedings of the Third International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2010) ISBN 978-989-674-017-7, pages 178-182. DOI: 10.5220/0002740301780182


in Bibtex Style

@conference{biodevices10,
author={Alberto Olmo and Alberto Yúfera},
title={COMPUTER SIMULATION OF MICROELECTRODE BASED BIO-IMPEDANCE MEASUREMENTS WITH COMSOL},
booktitle={Proceedings of the Third International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2010)},
year={2010},
pages={178-182},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0002740301780182},
isbn={978-989-674-017-7},
}


in EndNote Style

TY - CONF
JO - Proceedings of the Third International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2010)
TI - COMPUTER SIMULATION OF MICROELECTRODE BASED BIO-IMPEDANCE MEASUREMENTS WITH COMSOL
SN - 978-989-674-017-7
AU - Olmo A.
AU - Yúfera A.
PY - 2010
SP - 178
EP - 182
DO - 10.5220/0002740301780182